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train · 48.9k rows

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ID stringlengths 13 17	question stringlengths 88 1.13k	answer stringlengths 6 156	reference_sequence stringlengths 4.1k 4.1k	variant_sequence stringlengths 4.1k 4.1k
Task1_train_48200	A variant on Chromosome 21 has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?	Benign	TATGCAATACTGAGATTTGGGCTTCTATTGAACCCATCACCCAAACAATGAACACAGTACCCAATAATTCGTTTTTCAACTCTTGCTCCCCTCCCTCCCAGCTTTTGGAGTCCCCAGTGTCTACTGTTTCCACCTTTATGAGGTACTCAAGATATTGATCCAAACAACTACCCCGAGTCCTCAACCCATATGCCTCCACTAACAATGATGAAAATTACAACAGCTAACAAAGTTGCCCTTACTGGCTGCTTCCTAAGAACCAGGCACTATGCTTCACATATTATTTCATTCTACTTTCTCAAAAAACCTTATTACCCCCA...	TATGCAATACTGAGATTTGGGCTTCTATTGAACCCATCACCCAAACAATGAACACAGTACCCAATAATTCGTTTTTCAACTCTTGCTCCCCTCCCTCCCAGCTTTTGGAGTCCCCAGTGTCTACTGTTTCCACCTTTATGAGGTACTCAAGATATTGATCCAAACAACTACCCCGAGTCCTCAACCCATATGCCTCCACTAACAATGATGAAAATTACAACAGCTAACAAAGTTGCCCTTACTGGCTGCTTCCTAAGAACCAGGCACTATGCTTCACATATTATTTCATTCTACTTTCTCAAAAAACCTTATTACCCCCA...
Task1_train_48201	A mutation on Chromosome 21 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	ATGCAATACTGAGATTTGGGCTTCTATTGAACCCATCACCCAAACAATGAACACAGTACCCAATAATTCGTTTTTCAACTCTTGCTCCCCTCCCTCCCAGCTTTTGGAGTCCCCAGTGTCTACTGTTTCCACCTTTATGAGGTACTCAAGATATTGATCCAAACAACTACCCCGAGTCCTCAACCCATATGCCTCCACTAACAATGATGAAAATTACAACAGCTAACAAAGTTGCCCTTACTGGCTGCTTCCTAAGAACCAGGCACTATGCTTCACATATTATTTCATTCTACTTTCTCAAAAAACCTTATTACCCCCAT...	ATGCAATACTGAGATTTGGGCTTCTATTGAACCCATCACCCAAACAATGAACACAGTACCCAATAATTCGTTTTTCAACTCTTGCTCCCCTCCCTCCCAGCTTTTGGAGTCCCCAGTGTCTACTGTTTCCACCTTTATGAGGTACTCAAGATATTGATCCAAACAACTACCCCGAGTCCTCAACCCATATGCCTCCACTAACAATGATGAAAATTACAACAGCTAACAAAGTTGCCCTTACTGGCTGCTTCCTAAGAACCAGGCACTATGCTTCACATATTATTTCATTCTACTTTCTCAAAAAACCTTATTACCCCCAT...
Task1_train_48202	A mutation on Chromosome 21 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	CATCCTCTATTACAGATTTCCTCTAACACAGAATCAACAGGACTCTAATATTTCATACGTGGCTGTCACTGTGCTTTGAGGTTAATCTATATGGTCGTTTAAGCCCCGCCCCCCTAGAGGTTATTCCTTATCCCCACTTTACAGATGCGCAAACTGAGACACAGGAAGATAGAATAGCTCGGCCGGGATCACCCAGCTTGTGAGTGACACCGAGCAGGTACTGGAACCCGGGTTTGTTTGACCTCAGCGCACAGGCTCTAAACCTCTGCTCCAACTCAAAGTATGCGCCAAGTCAGCGTGCATGGGTAACCCGATCCGGA...	CATCCTCTATTACAGATTTCCTCTAACACAGAATCAACAGGACTCTAATATTTCATACGTGGCTGTCACTGTGCTTTGAGGTTAATCTATATGGTCGTTTAAGCCCCGCCCCCCTAGAGGTTATTCCTTATCCCCACTTTACAGATGCGCAAACTGAGACACAGGAAGATAGAATAGCTCGGCCGGGATCACCCAGCTTGTGAGTGACACCGAGCAGGTACTGGAACCCGGGTTTGTTTGACCTCAGCGCACAGGCTCTAAACCTCTGCTCCAACTCAAAGTATGCGCCAAGTCAGCGTGCATGGGTAACCCGATCCGGA...
Task1_train_48203	A variant was discovered on Chromosome 21. Please indicate if this mutation results in a known disease or if it's non-harmful.	Benign	CACTCAGGTGTAGCGGGCAGTTAGTCCCTGAGCGGGACTTGAACCTGCCTCCTGTCCTTCTATCTCCCATGCTGCTCCCGGAGAGAAGCCACTGTACCCACTTTGCCCAAAGCAACCTGCTTTCCCTGGGGCAGAGCATGCAGTGGATCGGGGAGGGGCAGCAGTGTCCATGTGGCAGCTGGAACACTGGAGACCTTGGCCATTAATGAAGTTTTACTTCTTTCTGCTGATGCATCTCAGGTGCCTGCGCCGGCCTTTCATTTCGGTGCCTGTGTGTTTATTTCTGCAAGGCAGGGAGGCTTCCCAGTGCCCTCAGCCAC...	CACTCAGGTGTAGCGGGCAGTTAGTCCCTGAGCGGGACTTGAACCTGCCTCCTGTCCTTCTATCTCCCATGCTGCTCCCGGAGAGAAGCCACTGTACCCACTTTGCCCAAAGCAACCTGCTTTCCCTGGGGCAGAGCATGCAGTGGATCGGGGAGGGGCAGCAGTGTCCATGTGGCAGCTGGAACACTGGAGACCTTGGCCATTAATGAAGTTTTACTTCTTTCTGCTGATGCATCTCAGGTGCCTGCGCCGGCCTTTCATTTCGGTGCCTGTGTGTTTATTTCTGCAAGGCAGGGAGGCTTCCCAGTGCCCTCAGCCAC...
Task1_train_48204	A variant affecting Chromosome 21 has been observed. Determine if it's benign or associated with disease.	Benign	GAATCTGAATTTTCCAAGGGGCCAGTGTAGAGTGACACAGGTGTCCGAGGCCACCTTTCCATCTTCAGACACCCCCCCGTCTCTCTGCACAGGGAGTTGGCCTTCCAGTAGGTGTTGCTCTTCTGTCTTGACGTCTCCTGGAAAGATTTTTATCTCTATTTTCCTGTGGTGGTGTTTTCCACGAGCTAATTCTTTCTATCTTTAAACTCATTGGCTGAAAACAAATGTGGGAATATTTTTGCATTAGTAACAATTATATTATTTTTAAATGTTAAGCAACACATCATACCAGCTATCACAGAATGTAGATGATTCTACTC...	GAATCTGAATTTTCCAAGGGGCCAGTGTAGAGTGACACAGGTGTCCGAGGCCACCTTTCCATCTTCAGACACCCCCCCGTCTCTCTGCACAGGGAGTTGGCCTTCCAGTAGGTGTTGCTCTTCTGTCTTGACGTCTCCTGGAAAGATTTTTATCTCTATTTTCCTGTGGTGGTGTTTTCCACGAGCTAATTCTTTCTATCTTTAAACTCATTGGCTGAAAACAAATGTGGGAATATTTTTGCATTAGTAACAATTATATTATTTTTAAATGTTAAGCAACACATCATACCAGCTATCACAGAATGTAGATGATTCTACTC...
Task1_train_48205	Here is a genetic alteration on Chromosome 21. Based on the data, is it a benign variant or a cause of disease?	Benign	CGCGTGTGGGGACGCTGCAGATTTCTTCCTGGCTTTCCACCGCTGCAGCTGCAGAGCTCTCAGCTTTTCTCGGAGCTCCATGTTCTGCTCCCTCAAAGCATCTATATGACTCCGGAGTTTTCCATGAACATCAGCCCACAGAGACTTCTGTCTCCCAAGCTCTTGGTGGAGTCTGATGATCTGCTGCTGTAATGGCTGTTATTGGGAAGAGAACACCAGAAAAACCTCTCAGATGTCACAATGGGCACATTTATCTGCAAAATACTCAAGCCCTCTCTGATGTAAGACCAACACTATTTCTGGAATAAAAGACACCCGAT...	CGCGTGTGGGGACGCTGCAGATTTCTTCCTGGCTTTCCACCGCTGCAGCTGCAGAGCTCTCAGCTTTTCTCGGAGCTCCATGTTCTGCTCCCTCAAAGCATCTATATGACTCCGGAGTTTTCCATGAACATCAGCCCACAGAGACTTCTGTCTCCCAAGCTCTTGGTGGAGTCTGATGATCTGCTGCTGTAATGGCTGTTATTGGGAAGAGAACACCAGAAAAACCTCTCAGATGTCACAATGGGCACATTTATCTGCAAAATACTCAAGCCCTCTCTGATGTAAGACCAACACTATTTCTGGAATAAAAGACACCCGAT...
Task1_train_48206	A mutation has occurred on Chromosome 21. What is the medical relevance of this mutation?	Benign	AGGAAAAAGAAATAAAGAAAGAAAGAAAGAGAAAGAAGAAAGAAAGAAAGAAAGAGAGAGGTAGGGAGGGAGAGAGGGAGGAAGGAAGGAGAAAGAGAAAGAAAAAGAAAGAAAGAGGAAAGAAAGAGAGAGAGAGAAAGAAGGAAAGAAGGAAGGAAAGAAGGGAGGGAGGGAGGGAGGGGAGAGGTTTGAAGAGGCTCACTCTGCCTGAAGACAGGAAGGGACCAGGAGCCGAGGCGCTCTCAGCCCCAGAAAGGGCAAGGAAGCAGAGCCCACCTCCAGCCTCCAGAACGAATGAGCCTGCCAAGGCCTGGGCTGTA...	AGGAAAAAGAAATAAAGAAAGAAAGAAAGAGAAAGAAGAAAGAAAGAAAGAAAGAGAGAGGTAGGGAGGGAGAGAGGGAGGAAGGAAGGAGAAAGAGAAAGAAAAAGAAAGAAAGAGGAAAGAAAGAGAGAGAGAGAAAGAAGGAAAGAAGGAAGGAAAGAAGGGAGGGAGGGAGGGAGGGGAGAGGTTTGAAGAGGCTCACTCTGCCTGAAGACAGGAAGGGACCAGGAGCCGAGGCGCTCTCAGCCCCAGAAAGGGCAAGGAAGCAGAGCCCACCTCCAGCCTCCAGAACGAATGAGCCTGCCAAGGCCTGGGCTGTA...
Task1_train_48207	A change on Chromosome 21 is being evaluated. Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.	Benign	CCCTCAATGTTGTGAGCTACAGGTTCTATATTCTCCCTTCTGCAGGCCCAGAGTGGTCACAGCCCTCAATGTTGTGAGCTACAGGTTCTATATTCTCCCTTCTGCAGGCCCAGAGTGGTCACAGCCCTCAATGTTGTGAGCTACAGGTTCTGGAGTCTCCCTTCTGGGCCCCAGAGTGGTCACAGGCCTCAATGTTGTGAGCTGCAGATTCTATACTCTCCCTTCTGGTTTGCCTACAGCCCTCTCACACATTTGTAAATATAGTCCTGCAACCCCTAATGATGTCTTGGGCAAAGATGGACCTTTTATATGACGATAGC...	CCCTCAATGTTGTGAGCTACAGGTTCTATATTCTCCCTTCTGCAGGCCCAGAGTGGTCACAGCCCTCAATGTTGTGAGCTACAGGTTCTATATTCTCCCTTCTGCAGGCCCAGAGTGGTCACAGCCCTCAATGTTGTGAGCTACAGGTTCTGGAGTCTCCCTTCTGGGCCCCAGAGTGGTCACAGGCCTCAATGTTGTGAGCTGCAGATTCTATACTCTCCCTTCTGGTTTGCCTACAGCCCTCTCACACATTTGTAAATATAGTCCTGCAACCCCTAATGATGTCTTGGGCAAAGATGGACCTTTTATATGACGATAGC...
Task1_train_48208	Chromosome 21 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	TGTACATTTATTTCCATCTGCAATTGTTTATTGCATTTTTTGAAATAAAGTCATTTAATTTTTCATCAACAGAATCAGCAGAATCTGCCAAAATAGGAGGAATAATTACTGTGTTTTTGATAGCATTGGTCTTGACAAGCACCATAGTGACACTGAAATGGATTGGTTATATATGCTTAAGAAATAGCCTCCCCAAAGTCTTGGTAGGTAGTTTTTTTGTTTTGTTTTGTTTTTTCTATCTTTGTTTTTTATTTTAACTTAAGAATTTGTATTTATATAAATATTTTCACAGAAGAAAATCTCATTTTCTATAAACACCA...	TGTACATTTATTTCCATCTGCAATTGTTTATTGCATTTTTTGAAATAAAGTCATTTAATTTTTCATCAACAGAATCAGCAGAATCTGCCAAAATAGGAGGAATAATTACTGTGTTTTTGATAGCATTGGTCTTGACAAGCACCATAGTGACACTGAAATGGATTGGTTATATATGCTTAAGAAATAGCCTCCCCAAAGTCTTGGTAGGTAGTTTTTTTGTTTTGTTTTGTTTTTTCTATCTTTGTTTTTTATTTTAACTTAAGAATTTGTATTTATATAAATATTTTCACAGAAGAAAATCTCATTTTCTATAAACACCA...
Task1_train_48209	Assess the clinical impact of this variant found on Chromosome 21. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	GAGGAAGCCGCGGAACCCCCAGCGTCCGTCCATGGCGTGGAGCCTTGGGAGCTGGCTGGGTGGCTGCCTGCTGGTGTCAGGTGAGGGGTCCGCGGGGAGGGGGCGCGCTTGGGAACCGGGAGGCCCCGCGAGATGCCGCCCCTGATCCCATCCCTGGGCGCCCTGCAAGTGACTTAAGAGCCTTCGGGGCCTCGGGAGAGAAGATGCAAACGCCACGGCCGGCTGCTGAGACGCAACTAGGCTGCTGCTGCCGTCGATTCTGTAACAGGAGAAAGCCCCATCCGCGCCCGGATTACAGACCGTCTGGGCCCTAAACTCAG...	GAGGAAGCCGCGGAACCCCCAGCGTCCGTCCATGGCGTGGAGCCTTGGGAGCTGGCTGGGTGGCTGCCTGCTGGTGTCAGGTGAGGGGTCCGCGGGGAGGGGGCGCGCTTGGGAACCGGGAGGCCCCGCGAGATGCCGCCCCTGATCCCATCCCTGGGCGCCCTGCAAGTGACTTAAGAGCCTTCGGGGCCTCGGGAGAGAAGATGCAAACGCCACGGCCGGCTGCTGAGACGCAACTAGGCTGCTGCTGCCGTCGATTCTGTAACAGGAGAAAGCCCCATCCGCGCCCGGATTACAGACCGTCTGGGCCCTAAACTCAG...
Task1_train_48210	This mutation occurs on Chromosome 21. Does this change lead to a known medical condition, or is it benign?	Benign	AGCACCCAGGGAAGCAATATGAGAAAAGAATATAAGAACAGAGACTGTGACAAAGCAAATTTAGATCCACAACATTGACATTTTTATAAAAAGGTTTTTGGAGGTTTATACTGAAAAGTTTTGTAACAATTATATTCATGTGTATCAGATTTGTAAGGTGTTCAAACCATTTTAACATATCCATTTGGCTTATAATTTTCATTACATTTTTAGTTTGAAAGAGTTTAATTGATTAAATTTTTAATCATTGTTTAAATACTCGAGGAACCCTAGTTTGTAAAATTCTAGTTTTTGATATAATAGTTATCTGAGCAGAATGT...	AGCACCCAGGGAAGCAATATGAGAAAAGAATATAAGAACAGAGACTGTGACAAAGCAAATTTAGATCCACAACATTGACATTTTTATAAAAAGGTTTTTGGAGGTTTATACTGAAAAGTTTTGTAACAATTATATTCATGTGTATCAGATTTGTAAGGTGTTCAAACCATTTTAACATATCCATTTGGCTTATAATTTTCATTACATTTTTAGTTTGAAAGAGTTTAATTGATTAAATTTTTAATCATTGTTTAAATACTCGAGGAACCCTAGTTTGTAAAATTCTAGTTTTTGATATAATAGTTATCTGAGCAGAATGT...
Task1_train_48211	This mutation is located on Chromosome 21. Is it associated with a disease or is it a benign polymorphism?	Benign	CTGTAGTAGTGGTTCTCAAAGAGTGATCCTCAAGGCCCTTTCAGGGGGCTGTAAAGACAAAGCTATATTTATGACAAATCTAAGACTTAGTTGCCTTTTTAATTTTTGTTCTTTCTTGTATTCACAGTGGAGTTTTCCAGAGGAGGCTGTTTGATGTGTGATGTGGTGATATGGTCACTGATTTAACATAGAATTCAATGTGAAATTCATCTGCCTTCTTTATTAATCCAAACATTCAAAAGATTTGGAAAAAAAATGTAAAACAGCACCACTCTGAAGTTTCTATGTTCCTTTTGGCAAATGTTTGTTACCATAAAATA...	CTGTAGTAGTGGTTCTCAAAGAGTGATCCTCAAGGCCCTTTCAGGGGGCTGTAAAGACAAAGCTATATTTATGACAAATCTAAGACTTAGTTGCCTTTTTAATTTTTGTTCTTTCTTGTATTCACAGTGGAGTTTTCCAGAGGAGGCTGTTTGATGTGTGATGTGGTGATATGGTCACTGATTTAACATAGAATTCAATGTGAAATTCATCTGCCTTCTTTATTAATCCAAACATTCAAAAGATTTGGAAAAAAAATGTAAAACAGCACCACTCTGAAGTTTCTATGTTCCTTTTGGCAAATGTTTGTTACCATAAAATA...
Task1_train_48212	This genomic variant is located on Chromosome 21. Can you determine its pathogenicity and name any linked disease?	Benign	GCTCCAGGTTTGGAAGAAGCCTGTGTAGGATCTGTGTTTCATTTCTGGCTTTGATGTCTGGGCGTCAGTTTCCCTGGGGTTAATTATTAGCTTAATGTGAAGGCAGCATTGTGGAAATTTCTCTGCATAGTTCGGATGCTATTCAGATCTGTCTGTGTGACTGTCATGCAGGCCTCTCTGTGTGACTGTGAGGGAGCATTGACCTGCCACCACCCCCCTCTGGAAGCATCCAGTCCCCAACTGGCTTTGGGCATTGCTAGGTCATAGCAGCCACAGCACACCTGGTGGGCCTGCCTCTTGCCACGCAGCTTTACCTGTCT...	GCTCCAGGTTTGGAAGAAGCCTGTGTAGGATCTGTGTTTCATTTCTGGCTTTGATGTCTGGGCGTCAGTTTCCCTGGGGTTAATTATTAGCTTAATGTGAAGGCAGCATTGTGGAAATTTCTCTGCATAGTTCGGATGCTATTCAGATCTGTCTGTGTGACTGTCATGCAGGCCTCTCTGTGTGACTGTGAGGGAGCATTGACCTGCCACCACCCCCCTCTGGAAGCATCCAGTCCCCAACTGGCTTTGGGCATTGCTAGGTCATAGCAGCCACAGCACACCTGGTGGGCCTGCCTCTTGCCACGCAGCTTTACCTGTCT...
Task1_train_48213	A mutation found on Chromosome 21 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	GAATCACTATGATCTTGGCCATCAAATAAAAAAAAATCACATATGCATTTAAGAACATACTGAATATTTGCAAGAATGTTCATAGCAGTGTTACTTACAATAGAGGGAAAAAAATCAGGCTACATCCATCTGAGAGAATACAATACTCTTATTACTTTACCCCTCTATCCATAAAGGTTAAACATAAACTTCTTCTAATTAATAAGATAACAATAAAAATTCCTCAACTGTTTTCAGACTTTTCAACAACAAAGCTATGATACAAAATGAGCTGTAGCTTCTATCTTTTCTGGTTTCTCTTTAACCAGCTTTCTGACATC...	GAATCACTATGATCTTGGCCATCAAATAAAAAAAAATCACATATGCATTTAAGAACATACTGAATATTTGCAAGAATGTTCATAGCAGTGTTACTTACAATAGAGGGAAAAAAATCAGGCTACATCCATCTGAGAGAATACAATACTCTTATTACTTTACCCCTCTATCCATAAAGGTTAAACATAAACTTCTTCTAATTAATAAGATAACAATAAAAATTCCTCAACTGTTTTCAGACTTTTCAACAACAAAGCTATGATACAAAATGAGCTGTAGCTTCTATCTTTTCTGGTTTCTCTTTAACCAGCTTTCTGACATC...
Task1_train_48214	A mutation found on Chromosome 21 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	CTGTCCCAGTTAAATAACTCCCCATTCCCCACTACCCCAGACCCTGGCAACCATCTGTTTAAAAGTAGATATACTGACATTTTGCTGCAACTTTTCTCAGTTCAATTTTGGTATGAACAAGAGAGGAATGCCTAATCAAGTCAAAAAAGTGAAAATTAGATTTGTAAAAACCGTACACAAGTATCCCTAAATAATTAAACTGAGTTCTTAATTTCAGTAATATATAACTGTATCTGTTTCCTAATAGCTGAGGACAGTAAACACTATGACAAAAGCAAAACCAGGTAAAGATACTCAGTGCATCATTTCCTTCTGTATAG...	CTGTCCCAGTTAAATAACTCCCCATTCCCCACTACCCCAGACCCTGGCAACCATCTGTTTAAAAGTAGATATACTGACATTTTGCTGCAACTTTTCTCAGTTCAATTTTGGTATGAACAAGAGAGGAATGCCTAATCAAGTCAAAAAAGTGAAAATTAGATTTGTAAAAACCGTACACAAGTATCCCTAAATAATTAAACTGAGTTCTTAATTTCAGTAATATATAACTGTATCTGTTTCCTAATAGCTGAGGACAGTAAACACTATGACAAAAGCAAAACCAGGTAAAGATACTCAGTGCATCATTTCCTTCTGTATAG...
Task1_train_48215	Assess the clinical impact of this variant found on Chromosome 21. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	TCCATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAACCAGCACCATGGATTCTCAGATGTTAGCAACCAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCAATGGATTCCCAGATGTTAGCATCTGGCACTATGGACTCTCAAATGTTAGCTTCTGGCACCATGGATGCTCAGATGTTAGCGTCTGGTACCATGGATGCCCAGATGTTAGCGTCTAGTACCCAAGATTCTGCTATGTTGGGTTCAAAATCTCCTGATCCCTATAGGTTAGCTCAGGATCCTTACAGGTTAGCTCAGGA...	TCCATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAACCAGCACCATGGATTCTCAGATGTTAGCAACCAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCAATGGATTCCCAGATGTTAGCATCTGGCACTATGGACTCTCAAATGTTAGCTTCTGGCACCATGGATGCTCAGATGTTAGCGTCTGGTACCATGGATGCCCAGATGTTAGCGTCTAGTACCCAAGATTCTGCTATGTTGGGTTCAAAATCTCCTGATCCCTATAGGTTAGCTCAGGATCCTTACAGGTTAGCTCAGGA...
Task1_train_48216	Consider a variant on Chromosome 21. Determine its clinical classification and disease relevance.	Benign	ATGCCCAGATGTTAGCGTCTAGTACCCAAGATTCTGCTATGTTGGGTTCAAAATCTCCTGATCCCTATAGGTTAGCTCAGGATCCTTACAGGTTAGCTCAGGATCCCTATAGGTTGGGCCATGACCCCTATAGATTAGGTCATGATGCTTACAGGTTAGGACAAGACCCTTATAGATTAGGCCATGATCCCTACAGACTAACTCCTGATCCCTATAGGATGTCACCTAGACCCTACAGGATAGCACCCAGGTCCTATAGAATAGCACCCAGGCCATATAGGTTAGCACCTAGACCCCTGATGTTAGCATCTAGACGTTCT...	ATGCCCAGATGTTAGCGTCTAGTACCCAAGATTCTGCTATGTTGGGTTCAAAATCTCCTGATCCCTATAGGTTAGCTCAGGATCCTTACAGGTTAGCTCAGGATCCCTATAGGTTGGGCCATGACCCCTATAGATTAGGTCATGATGCTTACAGGTTAGGACAAGACCCTTATAGATTAGGCCATGATCCCTACAGACTAACTCCTGATCCCTATAGGATGTCACCTAGACCCTACAGGATAGCACCCAGGTCCTATAGAATAGCACCCAGGCCATATAGGTTAGCACCTAGACCCCTGATGTTAGCATCTAGACGTTCT...
Task1_train_48217	Here is a variant on Chromosome 21. Please identify whether it is a benign mutation or associated with a disorder.	Benign	GTTTGGTTCCATGACATACCTCAGTATGTTTCAATTCTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCTAGGCTGGAGTGCAATGGCGCGATCTCAGCCCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGCACCACCACGCCCAGCTAATCTTTGTATTATTAGTAGAGACACAGTTTCACCACATTGGCCAGGCTGGTCTCGAACTCCTGATCTTGTGATCCACCCACCTCAGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACTACAC...	GTTTGGTTCCATGACATACCTCAGTATGTTTCAATTCTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCTAGGCTGGAGTGCAATGGCGCGATCTCAGCCCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGCACCACCACGCCCAGCTAATCTTTGTATTATTAGTAGAGACACAGTTTCACCACATTGGCCAGGCTGGTCTCGAACTCCTGATCTTGTGATCCACCCACCTCAGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACTACAC...
Task1_train_48218	An alteration has been detected on Chromosome 21. Is it pathogenic, and if so, what disease is involved?	Benign	ACATCCTGAGCGCACAGCTGCCGCACATGCAGCCCTACATCCGCTTCTGCAGCCGCCAGCTCAACGGGGCTGCCCTGATCCAGCAGAAGACGGATGAGGCCCCAGACTTCAAGGAGTTCGTCAAAGTAAGGAGCCAGGCTGTGCAGAGACTGGGCCCCAGAGTGGCGATCTTTGGGCAGCTGGATGTGTGAGGGGCTAATTCAAAAGTCTGCAAGAGTGTTCCCACTAGAGGCCAACAGGGCCTAGGGTCTTGGCTAAGCCTTAGGGGACTGGCACTCACTGGCAAGTGTGGCTGTCACCAAAGGGGTGGGCTTGGAGAG...	ACATCCTGAGCGCACAGCTGCCGCACATGCAGCCCTACATCCGCTTCTGCAGCCGCCAGCTCAACGGGGCTGCCCTGATCCAGCAGAAGACGGATGAGGCCCCAGACTTCAAGGAGTTCGTCAAAGTAAGGAGCCAGGCTGTGCAGAGACTGGGCCCCAGAGTGGCGATCTTTGGGCAGCTGGATGTGTGAGGGGCTAATTCAAAAGTCTGCAAGAGTGTTCCCACTAGAGGCCAACAGGGCCTAGGGTCTTGGCTAAGCCTTAGGGGACTGGCACTCACTGGCAAGTGTGGCTGTCACCAAAGGGGTGGGCTTGGAGAG...
Task1_train_48219	A mutation is present on Chromosome 21. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	TCTAAACCACTCTTTTCCAACACATTTTGATGTACTTTACATTTAACCCAGGCCTTATGAATAATCACTGGTTACAGAAGCACTAATAAGATACACGCTGGCTTTTCCAAAGCAAAGGGTCACAGAAGCTGATATAAAAATGAAACAAACATCCCAGGTGACAAGTTACCTTTCCCAATTTCTTGATTTTACCCTGTTTTTCCCTTTTCTTCCTGCAAAAGGTGACACATGTAATATCAAGGCAAACACAGCAGCAACAACCCGTTACTTACAGATGCAGAGGTCACTGTGCAAGGTACCTCTCCGCGATGGACACTCAT...	TCTAAACCACTCTTTTCCAACACATTTTGATGTACTTTACATTTAACCCAGGCCTTATGAATAATCACTGGTTACAGAAGCACTAATAAGATACACGCTGGCTTTTCCAAAGCAAAGGGTCACAGAAGCTGATATAAAAATGAAACAAACATCCCAGGTGACAAGTTACCTTTCCCAATTTCTTGATTTTACCCTGTTTTTCCCTTTTCTTCCTGCAAAAGGTGACACATGTAATATCAAGGCAAACACAGCAGCAACAACCCGTTACTTACAGATGCAGAGGTCACTGTGCAAGGTACCTCTCCGCGATGGACACTCAT...
Task1_train_48220	A genetic alteration is present on Chromosome 21. Is this variant benign or disease-causing, and if the latter, which condition is involved?	Benign	AAAGTAGGTATTGGGTCTGTGATCCTGGGAGAACCCTAACCCAGGGAATTCCATAGCTCCCCTCTTTCACATCTTGGATTTTCTTTTCTCCACCTCCAGATTCCCAAGCTCTTAACTTGGAGGCAGAAGCACTGGTGGTGAGTTTAGAAATCTAGGAGAATCAGCAAGATACACAGACTCTTACAGTCTTAAGAGACCCGGGAGATGAAGGTGTAACCTTTTTCCAGCGCAGGGCTCCCACGATCCTCCAGACAGGCCCGGAGAAGCGGACCCTCATGGACAACAGCGCCCATCTCTGGTCAGAGAAACTCGACTGGCTC...	AAAGTAGGTATTGGGTCTGTGATCCTGGGAGAACCCTAACCCAGGGAATTCCATAGCTCCCCTCTTTCACATCTTGGATTTTCTTTTCTCCACCTCCAGATTCCCAAGCTCTTAACTTGGAGGCAGAAGCACTGGTGGTGAGTTTAGAAATCTAGGAGAATCAGCAAGATACACAGACTCTTACAGTCTTAAGAGACCCGGGAGATGAAGGTGTAACCTTTTTCCAGCGCAGGGCTCCCACGATCCTCCAGACAGGCCCGGAGAAGCGGACCCTCATGGACAACAGCGCCCATCTCTGGTCAGAGAAACTCGACTGGCTC...
Task1_train_48221	The following genetic variant occurs on Chromosome 21. Classify its clinical effect — pathogenic or benign — and list any associated condition.	Benign	AAGGAGTACGGGGGCCTGGACGTGCTGGTCAACAACGCGGGCATCGCCTTCAAGGGTATGGGGAGGGGACGTGGCCTCCCCGAAGAAGAACCGATGCACTGGGGCTCCTGGCGTCTGCGGGGTCCATAACGCCTCCCTAGGGAGGAGAGGGAGGAGCTAGGAGATGCAGGGAGTGCAGAAACCTTGGAGAAAGTGAGAGTTTTCCAGCCAAAGGGAACTTTGTGTTTCCCTGGCTGGGACTCTTGGGGATCTTTTTCAGGTTTTCTGCAGTTTTTCTGAATTGAGCTTTAAGGCAACTGGATGGATTTTGAACTGATTTT...	AAGGAGTACGGGGGCCTGGACGTGCTGGTCAACAACGCGGGCATCGCCTTCAAGGGTATGGGGAGGGGACGTGGCCTCCCCGAAGAAGAACCGATGCACTGGGGCTCCTGGCGTCTGCGGGGTCCATAACGCCTCCCTAGGGAGGAGAGGGAGGAGCTAGGAGATGCAGGGAGTGCAGAAACCTTGGAGAAAGTGAGAGTTTTCCAGCCAAAGGGAACTTTGTGTTTCCCTGGCTGGGACTCTTGGGGATCTTTTTCAGGTTTTCTGCAGTTTTTCTGAATTGAGCTTTAAGGCAACTGGATGGATTTTGAACTGATTTT...
Task1_train_48222	Consider a variant on Chromosome 21. Determine its clinical classification and disease relevance.	Benign	GAACTAGGCCAGGCACGGTGACACAAGCCTGTAATACCAGCACTTTGAGAGGCCAAGGAGGGAGAATCGATGTAGCCCAGGAGTTCAACCAGTCTGAGCAACACAGTGAGACTCCCATCTCTAAAAACAAATAAAAATAAAATAAAATAAAAAATTATCCAGGCAGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTATCTACTAAAAATACAAAAATTAGCTGGGTGTAGTGGCAGCGCC...	GAACTAGGCCAGGCACGGTGACACAAGCCTGTAATACCAGCACTTTGAGAGGCCAAGGAGGGAGAATCGATGTAGCCCAGGAGTTCAACCAGTCTGAGCAACACAGTGAGACTCCCATCTCTAAAAACAAATAAAAATAAAATAAAATAAAAAATTATCCAGGCAGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTATCTACTAAAAATACAAAAATTAGCTGGGTGTAGTGGCAGCGCC...
Task1_train_48223	A genomic variant on Chromosome 21 is under review. What is the biological outcome — benign or pathogenic?	Benign	AAGCAGTAGAATCACTTGATCCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTGCAGCCTAGGCAACAAAACAAGACTGTCTCACAAAACAAAATAAAAAATTTTTAGGCCGGGTGTAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCTGAAGCAGTAGAATCACTTGATCCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTGCAGCCTAGGCAACAAAACAAGACTCTGTCTCACAAAACAAAATAAAAAAATTTTAGGCCAGGTGTAGTGGCTCACGCCTGTAAT...	AAGCAGTAGAATCACTTGATCCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTGCAGCCTAGGCAACAAAACAAGACTGTCTCACAAAACAAAATAAAAAATTTTTAGGCCGGGTGTAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCTGAAGCAGTAGAATCACTTGATCCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTGCAGCCTAGGCAACAAAACAAGACTCTGTCTCACAAAACAAAATAAAAAAATTTTAGGCCAGGTGTAGTGGCTCACGCCTGTAAT...
Task1_train_48224	Chromosome 21 houses a mutation. Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?	Benign	TTTTTTTAAATAGGCAGTGGTCAGTGGCCTATTTGACTTCTCCTAAAAAAGACTTCAATATTTTAAAGTGTCATACGTTTTCTGATTATAGAAGTACTAACATGGTTAGTTTTAAAATGGAAATAATGAGGACATAAAAACCTAAGTGGAAGTCCTTTGTAATGCTAGTTGATAGAACTAGGGATTGTTAATGGCTTGCAGGTAGTCTCCCAGACTTTCCTAGTGGCTGTGTATTATACATACTCTCTCCTAACTGGGCTCATTCTACATAATACTCTTCTGCTGCTTGATTTTTTTTTTCCTTTCTTTTTAGAGACAGG...	TTTTTTTAAATAGGCAGTGGTCAGTGGCCTATTTGACTTCTCCTAAAAAAGACTTCAATATTTTAAAGTGTCATACGTTTTCTGATTATAGAAGTACTAACATGGTTAGTTTTAAAATGGAAATAATGAGGACATAAAAACCTAAGTGGAAGTCCTTTGTAATGCTAGTTGATAGAACTAGGGATTGTTAATGGCTTGCAGGTAGTCTCCCAGACTTTCCTAGTGGCTGTGTATTATACATACTCTCTCCTAACTGGGCTCATTCTACATAATACTCTTCTGCTGCTTGATTTTTTTTTTCCTTTCTTTTTAGAGACAGG...
Task1_train_48225	Consider a variant on Chromosome 21. Determine its clinical classification and disease relevance.	Benign	AATTTGTTACATTCCTAGGAAACCTTAAGCTATGGAAGAAAAAAAAAGTCTCATTCTACAAACAAGACATTTCAGGGGAGAAGCAGGGGAGAGTGTTAGGGGCTAGAGAGTGTTATTTGAAACACTTTTCCCTCCATAGGAATGAAAGTTTTTGTCATGGCCATCAAGTTTAAACCTTACTCAGTAAATCTGTTATATTTACTTGCTCCGCTTCCCACCCACCACCCTCAAAATATGGTGTTGTCTGCCAGCCAGTCCATATGATTGTGTAAGTCCATTCCTCACCATGGGCTGCTTGGTTTCTGCGTCTCCTCATTCAT...	AATTTGTTACATTCCTAGGAAACCTTAAGCTATGGAAGAAAAAAAAAGTCTCATTCTACAAACAAGACATTTCAGGGGAGAAGCAGGGGAGAGTGTTAGGGGCTAGAGAGTGTTATTTGAAACACTTTTCCCTCCATAGGAATGAAAGTTTTTGTCATGGCCATCAAGTTTAAACCTTACTCAGTAAATCTGTTATATTTACTTGCTCCGCTTCCCACCCACCACCCTCAAAATATGGTGTTGTCTGCCAGCCAGTCCATATGATTGTGTAAGTCCATTCCTCACCATGGGCTGCTTGGTTTCTGCGTCTCCTCATTCAT...
Task1_train_48226	A mutation is present on Chromosome 21. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	CCTCCCGGCGGCCTCAGTCCCAGCTTCCCGGGCCCAGCGCCCGGTCCCTGGGAAAGGCGGGGTTCTCCTCTCGCCCCGCCGCCCCGGTCCCCTACCCCGTTTGGCCCCCTCTTCCGGGAGGCTCCTCCCGGGGCGGGCCCCTCCCCGGGCTCTCAGGGCGCGCCCCTAGCCCCTACTAAGCGGGGACAGGCCGTGCAGACGGCCGGGGCCCCTAGGTAGCCTTTACCTGGGTGTTTCGTTTTGCTTTTCTGGATGTAGCGGCGTATCATAAACTTGTGGATGTCAGGACCCAGCGAAGCATTTTAGGTGGAGCTAGCAAG...	CCTCCCGGCGGCCTCAGTCCCAGCTTCCCGGGCCCAGCGCCCGGTCCCTGGGAAAGGCGGGGTTCTCCTCTCGCCCCGCCGCCCCGGTCCCCTACCCCGTTTGGCCCCCTCTTCCGGGAGGCTCCTCCCGGGGCGGGCCCCTCCCCGGGCTCTCAGGGCGCGCCCCTAGCCCCTACTAAGCGGGGACAGGCCGTGCAGACGGCCGGGGCCCCTAGGTAGCCTTTACCTGGGTGTTTCGTTTTGCTTTTCTGGATGTAGCGGCGTATCATAAACTTGTGGATGTCAGGACCCAGCGAAGCATTTTAGGTGGAGCTAGCAAG...
Task1_train_48227	A sequence alteration has been identified on Chromosome 21. Is it disease-inducing or harmless?	Benign	CCACTTCGTATCCTCCTTCCCTTTGCTTAATTTCTCCCCATAGTACGTTATCACCTGATACTATATACGTTTTTCTTATTTAACTTGCCCATTGACTATCTCCCCCCGGCATGAGAATGAAGACTCAAAGCAGGGCATTTTTGGCTGTTTTGGTCCTTCCTGGCCTGTAACAGTGCCTGGCACATGGTAAGCACCAATAAATACTTGAATTACTTTTTGGTTGTGGGTATGATGGAATTTAATTTTGTTTTGAGACAGTTTCGCTCGTTGCCCAGGCTGGAGTGCAAAAGTGCAATCTCAGCTCACGGCAACCTCCGCCT...	CCACTTCGTATCCTCCTTCCCTTTGCTTAATTTCTCCCCATAGTACGTTATCACCTGATACTATATACGTTTTTCTTATTTAACTTGCCCATTGACTATCTCCCCCCGGCATGAGAATGAAGACTCAAAGCAGGGCATTTTTGGCTGTTTTGGTCCTTCCTGGCCTGTAACAGTGCCTGGCACATGGTAAGCACCAATAAATACTTGAATTACTTTTTGGTTGTGGGTATGATGGAATTTAATTTTGTTTTGAGACAGTTTCGCTCGTTGCCCAGGCTGGAGTGCAAAAGTGCAATCTCAGCTCACGGCAACCTCCGCCT...
Task1_train_48228	A mutation found on Chromosome 21 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	GTTTTTTAAAATGATTTTTATGGAAAATTAAAACTTAAAGAGAACTAGCCTAGAATGATTAAATACTAAAAACTTGATTCAGAATTATTTATCTAGTGGTTGAATTTACAATTAAAATTATAACATTTGATGCTGTGAAATTACATGTTTGATTAATAGATTTGGCATTTATATAAAAACTATACAGTTTGCTCTCAGTTGTTGAAACTTTAATTCCAAAAGCATATTTTTCTTTTTATCTCTCTTCAGTAAACATTTTGAACCTATGACTATTTTTTACCCTGAAATACTCAATGTACTGTCTAAATTATTACTTCTCT...	GTTTTTTAAAATGATTTTTATGGAAAATTAAAACTTAAAGAGAACTAGCCTAGAATGATTAAATACTAAAAACTTGATTCAGAATTATTTATCTAGTGGTTGAATTTACAATTAAAATTATAACATTTGATGCTGTGAAATTACATGTTTGATTAATAGATTTGGCATTTATATAAAAACTATACAGTTTGCTCTCAGTTGTTGAAACTTTAATTCCAAAAGCATATTTTTCTTTTTATCTCTCTTCAGTAAACATTTTGAACCTATGACTATTTTTTACCCTGAAATACTCAATGTACTGTCTAAATTATTACTTCTCT...
Task1_train_48229	Assess the clinical impact of this variant found on Chromosome 21. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	TGAGTAATAAGTGTGCCTAAAAATTATTTGTATCTCATTTCTCCCTCATTCATTCATTCGGTAATTAGTGGTGATAAAGACTGATGTGGGCTGTGCCCTCAAAGTGCACATGGACTTGGGGAAAGGCAGACTTTAAACCCATTGTTACCTGCAGCAGAGTGAGGTTTCTCATGGCAGAATGCTGGAGCGGCGTGGATCAGGGGCCACTAACCTAATCTAGAGGTGTGGCCTCAGCGGGAGATTCCCAGTTGGAAGTCTCCCAGAGACAGAGATCTGCAATAGGAACTTACCAGACAAAGGAGTGAGAGGGGTGTGTTTGG...	TGAGTAATAAGTGTGCCTAAAAATTATTTGTATCTCATTTCTCCCTCATTCATTCATTCGGTAATTAGTGGTGATAAAGACTGATGTGGGCTGTGCCCTCAAAGTGCACATGGACTTGGGGAAAGGCAGACTTTAAACCCATTGTTACCTGCAGCAGAGTGAGGTTTCTCATGGCAGAATGCTGGAGCGGCGTGGATCAGGGGCCACTAACCTAATCTAGAGGTGTGGCCTCAGCGGGAGATTCCCAGTTGGAAGTCTCCCAGAGACAGAGATCTGCAATAGGAACTTACCAGACAAAGGAGTGAGAGGGGTGTGTTTGG...
Task1_train_48230	A genetic alteration is present on Chromosome 21. Is this variant benign or disease-causing, and if the latter, which condition is involved?	Benign	ATTGTGTGGTTACTTCCTGTGTCCTGACAACTTGTGCCTGGATCCCTGATGTGATCATTTAGATCTGGTAGAAATACCAGGTGGAGTCAGCCTCCTAAAGATGGAACAGTGGGTAACAGGTGTAGAAGCTGGGGCATGAGGTGGTGGCGTGCTCTCCTTGCATGAAGGCCCTCTCTCCCCTGCTGCTCCCGCTGTTGGTGCTGATGTTCAGACTCATGGACAGTGAGCCCTACAATGTGTCATACCCCTGGGGCTGAGGGCAAGAGGGAAAGGGAACAATGGCCCACACCAAAATGTAAAAGGCCCTCCGGGAGTTCTGG...	ATTGTGTGGTTACTTCCTGTGTCCTGACAACTTGTGCCTGGATCCCTGATGTGATCATTTAGATCTGGTAGAAATACCAGGTGGAGTCAGCCTCCTAAAGATGGAACAGTGGGTAACAGGTGTAGAAGCTGGGGCATGAGGTGGTGGCGTGCTCTCCTTGCATGAAGGCCCTCTCTCCCCTGCTGCTCCCGCTGTTGGTGCTGATGTTCAGACTCATGGACAGTGAGCCCTACAATGTGTCATACCCCTGGGGCTGAGGGCAAGAGGGAAAGGGAACAATGGCCCACACCAAAATGTAAAAGGCCCTCCGGGAGTTCTGG...
Task1_train_48231	Assess the clinical impact of this variant found on Chromosome 21. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	GTAGCTGGAAATGATGGCCACAATTCCTCAGACGCCTGCCGGCTCTTTCTTCCACGTCTTTAGTAGGGGATCAACAAGGTCACTTACTGTAGGGAGTGATTTACTCCGCCTTCCCTGGATCACATCAGATTGATTCTAATCAGATATCTATGTACTGTTACTCCCTGAACAAGCATTTGGCAGTACTGGTAGTGGGGAGCCAAGATGGATTTAATTTCCTTTGGCCGATATGCTTCATTTTCATGATAACATTTCTCAAAACTTAACGGAGGGGCTCTTGATTTCTGAATCTGCCCTTTTTTCTAGAAGGGTAAGGCAGG...	GTAGCTGGAAATGATGGCCACAATTCCTCAGACGCCTGCCGGCTCTTTCTTCCACGTCTTTAGTAGGGGATCAACAAGGTCACTTACTGTAGGGAGTGATTTACTCCGCCTTCCCTGGATCACATCAGATTGATTCTAATCAGATATCTATGTACTGTTACTCCCTGAACAAGCATTTGGCAGTACTGGTAGTGGGGAGCCAAGATGGATTTAATTTCCTTTGGCCGATATGCTTCATTTTCATGATAACATTTCTCAAAACTTAACGGAGGGGCTCTTGATTTCTGAATCTGCCCTTTTTTCTAGAAGGGTAAGGCAGG...
Task1_train_48232	A variant on Chromosome 21 is under investigation. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.	Benign	ATTTCCTTTGGCCGATATGCTTCATTTTCATGATAACATTTCTCAAAACTTAACGGAGGGGCTCTTGATTTCTGAATCTGCCCTTTTTTCTAGAAGGGTAAGGCAGGAAGGTAAGATCTCATTCTCAGATGATTAAGACCAGCACCCTCCTGCAGTATCCACGCTCCCACCCTGGGGCTTTCCTTTGAAATCAGCAAGAGTCTGTGTAGATGAAGAGATACGAGTCAGGAGCAGGTCCACATAGAAGCGGCTTTCCCATATTAATAATAATGTTTCACAATAATATCACTTTGGGTGCTTCCTCTACTCCTTGGAGCCAT...	ATTTCCTTTGGCCGATATGCTTCATTTTCATGATAACATTTCTCAAAACTTAACGGAGGGGCTCTTGATTTCTGAATCTGCCCTTTTTTCTAGAAGGGTAAGGCAGGAAGGTAAGATCTCATTCTCAGATGATTAAGACCAGCACCCTCCTGCAGTATCCACGCTCCCACCCTGGGGCTTTCCTTTGAAATCAGCAAGAGTCTGTGTAGATGAAGAGATACGAGTCAGGAGCAGGTCCACATAGAAGCGGCTTTCCCATATTAATAATAATGTTTCACAATAATATCACTTTGGGTGCTTCCTCTACTCCTTGGAGCCAT...
Task1_train_48233	A mutation on Chromosome 21 has been found. Is it harmful or harmless? What disease, if any, does it cause?	Benign	ATGCATGCAGTCACTTGCAGACAGGCTGCATTTGTCTCTGCTGGTGCTCATGTTACAAGTTTGTCTGTGCATTTGGGCATGCCAGAATGGCGTTTCATTTCCAAACCTTTATTGTGGTCACTTTCCTCTTCGTTACACTGAGAAGTGTTGCTGAGGGTATAGTAAGGCCCTAGTTCATCAATTATATCCTGTACTTTTCTTCTAACTTGATCCCAAGAACAGTGGAATTTGCTTCAAGGTAAACAAATTTTGAATAATTTATGGCCCTTCTTTTCAACAAAAATGAAAACGTGACTTTCTAAAGAAAAGTCAATTACAAG...	ATGCATGCAGTCACTTGCAGACAGGCTGCATTTGTCTCTGCTGGTGCTCATGTTACAAGTTTGTCTGTGCATTTGGGCATGCCAGAATGGCGTTTCATTTCCAAACCTTTATTGTGGTCACTTTCCTCTTCGTTACACTGAGAAGTGTTGCTGAGGGTATAGTAAGGCCCTAGTTCATCAATTATATCCTGTACTTTTCTTCTAACTTGATCCCAAGAACAGTGGAATTTGCTTCAAGGTAAACAAATTTTGAATAATTTATGGCCCTTCTTTTCAACAAAAATGAAAACGTGACTTTCTAAAGAAAAGTCAATTACAAG...
Task1_train_48234	Consider this mutation on Chromosome 21. Is this a benign change or a disease-causing variant?	Benign	CTGCTCATATATGTTGGAAACAGCCCAGCATGAGCAAAGCACCACCTCCTAGCCCCCAGCCTGTGCCAGCCCTGCAAAGAGGAAATATGGCTCCACTCAGGGAGCCCATCAGCGACTCAGGGAGCCCTGGAGCACCTGGCACTCAGCACCCATGAACACGAGGGCAGGCATGGTGGGACAAGGCAGTCTGCTTGGGGCAAGTGAGCTTCGGGAAGTAGCTGAGCTTTGGGGAGCAGCTGTCTATACCCAGCTTCTCAGGGCTGTGCAAGTAGCCTGAGGGAGAAAGACCCTATATTAGCTGAAACTGCAGCCCAGATGAG...	CTGCTCATATATGTTGGAAACAGCCCAGCATGAGCAAAGCACCACCTCCTAGCCCCCAGCCTGTGCCAGCCCTGCAAAGAGGAAATATGGCTCCACTCAGGGAGCCCATCAGCGACTCAGGGAGCCCTGGAGCACCTGGCACTCAGCACCCATGAACACGAGGGCAGGCATGGTGGGACAAGGCAGTCTGCTTGGGGCAAGTGAGCTTCGGGAAGTAGCTGAGCTTTGGGGAGCAGCTGTCTATACCCAGCTTCTCAGGGCTGTGCAAGTAGCCTGAGGGAGAAAGACCCTATATTAGCTGAAACTGCAGCCCAGATGAG...
Task1_train_48235	This sequence change occurs on Chromosome 21. What is the medical significance of this variant — is it benign or linked to a disease?	Benign	TGCTCATATATGTTGGAAACAGCCCAGCATGAGCAAAGCACCACCTCCTAGCCCCCAGCCTGTGCCAGCCCTGCAAAGAGGAAATATGGCTCCACTCAGGGAGCCCATCAGCGACTCAGGGAGCCCTGGAGCACCTGGCACTCAGCACCCATGAACACGAGGGCAGGCATGGTGGGACAAGGCAGTCTGCTTGGGGCAAGTGAGCTTCGGGAAGTAGCTGAGCTTTGGGGAGCAGCTGTCTATACCCAGCTTCTCAGGGCTGTGCAAGTAGCCTGAGGGAGAAAGACCCTATATTAGCTGAAACTGCAGCCCAGATGAGT...	TGCTCATATATGTTGGAAACAGCCCAGCATGAGCAAAGCACCACCTCCTAGCCCCCAGCCTGTGCCAGCCCTGCAAAGAGGAAATATGGCTCCACTCAGGGAGCCCATCAGCGACTCAGGGAGCCCTGGAGCACCTGGCACTCAGCACCCATGAACACGAGGGCAGGCATGGTGGGACAAGGCAGTCTGCTTGGGGCAAGTGAGCTTCGGGAAGTAGCTGAGCTTTGGGGAGCAGCTGTCTATACCCAGCTTCTCAGGGCTGTGCAAGTAGCCTGAGGGAGAAAGACCCTATATTAGCTGAAACTGCAGCCCAGATGAGT...
Task1_train_48236	A mutation on Chromosome 21 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	CTGCACATCTTCGAGTAATCCTCAGGAGACCTGTTCTGGCTTTTGATGATTTCTTAACCACCTGTAAACTACTGTCTGAGTCACTGGAACAGACCCTTTTCCTGGAAATTTTTCTGCTTAGTCCATTGTCTTGTGATGCAGAATCTAAAAGTTAAAGAGCAGATTTCTATTAATCTTTTGTAAGTCTAAAGGAATTATATGTTCAATATTAAAAACAAGTTCAGAATTCGTATTAATTTGAAGGGGGTATTGCAGTGAATGGAATGGTACACACCTATTAGTATAGTCATATGTTGCTCAACAGCAAGGATACGTTCTGA...	CTGCACATCTTCGAGTAATCCTCAGGAGACCTGTTCTGGCTTTTGATGATTTCTTAACCACCTGTAAACTACTGTCTGAGTCACTGGAACAGACCCTTTTCCTGGAAATTTTTCTGCTTAGTCCATTGTCTTGTGATGCAGAATCTAAAAGTTAAAGAGCAGATTTCTATTAATCTTTTGTAAGTCTAAAGGAATTATATGTTCAATATTAAAAACAAGTTCAGAATTCGTATTAATTTGAAGGGGGTATTGCAGTGAATGGAATGGTACACACCTATTAGTATAGTCATATGTTGCTCAACAGCAAGGATACGTTCTGA...
Task1_train_48237	Located on Chromosome 21, this mutation has been observed. What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?	Benign	ACTACTGGAAGCTGACGATGACAAAGAGGTAGCTAAAGAATCTTCCACTTCACTTTCTAGGAAAAATAAAGTGTAAATAGTTACATATATTCTCCTGTCTTTACACACATAAGCAAGCAGTTCATAACATTACTCTGAACATTACATAACATTACTACAAAAGCAGATTCCTAAAATGCTTAGAATATATTTTTTAAAAACCATTCCCAAAAAAAGCTGATGAAATTTGGAGTATTAAAAGGTACATAATCAGCATTCCAAATAGTTTTTAATTATATTTCTAAAAATAACAGATTAATCCTAGTGTAGATTTACAAAAT...	ACTACTGGAAGCTGACGATGACAAAGAGGTAGCTAAAGAATCTTCCACTTCACTTTCTAGGAAAAATAAAGTGTAAATAGTTACATATATTCTCCTGTCTTTACACACATAAGCAAGCAGTTCATAACATTACTCTGAACATTACATAACATTACTACAAAAGCAGATTCCTAAAATGCTTAGAATATATTTTTTAAAAACCATTCCCAAAAAAAGCTGATGAAATTTGGAGTATTAAAAGGTACATAATCAGCATTCCAAATAGTTTTTAATTATATTTCTAAAAATAACAGATTAATCCTAGTGTAGATTTACAAAAT...
Task1_train_48238	A mutation on Chromosome 21 has been found. Is it harmful or harmless? What disease, if any, does it cause?	Benign	TCAAAGCTTCTTTGCCGTCAGTTCATGACACATCACTATCCTCTGCATTTGCTTTTACTGTATCCTCACTATTCCCTATAAACTCTGCTCTGGCAGTCCGTGCAGAGATCTATGATCCCATAGGGCTTGTTTTTAAAGGATTCTTGCCTACTGATCAGCCCACAGGCAAAACAACACACCAAGTGTACAGAGGTTTAAATTCTGTTCCAAGGATCCCTATTTAGTGATAACCTCAACAAGGTCTGTTCTCCGGCCGTTTTCACTGTTGCCAAGTCAAGAGTTGCCCCACACCACCTCTGAAGACTATACTTAAGAGGGCA...	TCAAAGCTTCTTTGCCGTCAGTTCATGACACATCACTATCCTCTGCATTTGCTTTTACTGTATCCTCACTATTCCCTATAAACTCTGCTCTGGCAGTCCGTGCAGAGATCTATGATCCCATAGGGCTTGTTTTTAAAGGATTCTTGCCTACTGATCAGCCCACAGGCAAAACAACACACCAAGTGTACAGAGGTTTAAATTCTGTTCCAAGGATCCCTATTTAGTGATAACCTCAACAAGGTCTGTTCTCCGGCCGTTTTCACTGTTGCCAAGTCAAGAGTTGCCCCACACCACCTCTGAAGACTATACTTAAGAGGGCA...
Task1_train_48239	Located on Chromosome 21, this mutation has been observed. What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?	Benign	ATAATGAGGAACTAAAAGGATCAGTTTTGAATTTATCACTTTCATTTAGGTGTTTGAAGAATCTGAAAAGCACAGGTATTAATATGACCATACTAACTTGATACATTAAGTTCAAAATTTAAGCCATGTTAAAGAAACATAAAAATACTTTTAGATACCATCCATCAATACTGAGAAGAAAGCTTAACATTTATTCCTTGTTAGTAAGTATACAGCAGCAGCTAAATTAGTTTAGCCCCCAGCGGGTGGTATAAAAGACCCATACGGATACTGACCAATTACTTGAATTAAAGGGCCATAAAGACAAGCAAGTAGAGCTC...	ATAATGAGGAACTAAAAGGATCAGTTTTGAATTTATCACTTTCATTTAGGTGTTTGAAGAATCTGAAAAGCACAGGTATTAATATGACCATACTAACTTGATACATTAAGTTCAAAATTTAAGCCATGTTAAAGAAACATAAAAATACTTTTAGATACCATCCATCAATACTGAGAAGAAAGCTTAACATTTATTCCTTGTTAGTAAGTATACAGCAGCAGCTAAATTAGTTTAGCCCCCAGCGGGTGGTATAAAAGACCCATACGGATACTGACCAATTACTTGAATTAAAGGGCCATAAAGACAAGCAAGTAGAGCTC...