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train · 48.9k rows

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ID stringlengths 13 17	question stringlengths 88 1.13k	answer stringlengths 6 156	reference_sequence stringlengths 4.1k 4.1k	variant_sequence stringlengths 4.1k 4.1k
Task1_train_48300	Given this variant on Chromosome 21, classify it as benign or pathogenic. Include the disorder it may cause if applicable.	Benign	CAAGGACAGTGCTCCGGGGTCTGCAGCTCTGTCTCAAAGGAAGAGAGAAACAGGTTCATAGGCCCAGGGAACCACACAGGCATGCTCTGGGGGCCTCCGTTGTGTCACACCGTCTGGGATCAGGACTCAGTTCTGAGTAGACCCCCTCGGCCTGCCCTGCCTGATGAGGTGTTAGAACCTGTTCAGCTGCCACTCAGCTGCTGCACCCAGGTGGTCGCCTGTGGCTGATGCCCGGGACAGTGGCTGCCTCCCTCCTGGGCGACGTGGTGTGGCGAGCGCCTGCGTCAGGCCCACTTCTGGCTGCGTGGAGTTGGCGTTTC...	CAAGGACAGTGCTCCGGGGTCTGCAGCTCTGTCTCAAAGGAAGAGAGAAACAGGTTCATAGGCCCAGGGAACCACACAGGCATGCTCTGGGGGCCTCCGTTGTGTCACACCGTCTGGGATCAGGACTCAGTTCTGAGTAGACCCCCTCGGCCTGCCCTGCCTGATGAGGTGTTAGAACCTGTTCAGCTGCCACTCAGCTGCTGCACCCAGGTGGTCGCCTGTGGCTGATGCCCGGGACAGTGGCTGCCTCCCTCCTGGGCGACGTGGTGTGGCGAGCGCCTGCGTCAGGCCCACTTCTGGCTGCGTGGAGTTGGCGTTTC...
Task1_train_48301	Given this variant on Chromosome 21, classify it as benign or pathogenic. Include the disorder it may cause if applicable.	Benign	GTATGCGATCCCTGTGTAAGTTGGGGACATTTTGGACTGAGAAAGACAATGAGGGAGAGAAGAAAAAAATCTTTCACAGACGCACACACTCAAGTTCTCCCAGCAGGGCTTATTCTCTGCCTGCCTTTGGGGCAGCGGCAAGGGGGTACAAGGCTAGATGTGACCAAGAAGAGGGGGTGTAGACCTTCAACTTCCCCGTAACAAAGTAAAACAAGCCCTCCTGGGATTCCTTTCCAGGTGAGAGCAAGTTCCAAACTATTGCTCCCCTCCTCTGCGACCAAGTGACAAAGGGTGTTTCATTTATAGGGATGTTGACGGGA...	GTATGCGATCCCTGTGTAAGTTGGGGACATTTTGGACTGAGAAAGACAATGAGGGAGAGAAGAAAAAAATCTTTCACAGACGCACACACTCAAGTTCTCCCAGCAGGGCTTATTCTCTGCCTGCCTTTGGGGCAGCGGCAAGGGGGTACAAGGCTAGATGTGACCAAGAAGAGGGGGTGTAGACCTTCAACTTCCCCGTAACAAAGTAAAACAAGCCCTCCTGGGATTCCTTTCCAGGTGAGAGCAAGTTCCAAACTATTGCTCCCCTCCTCTGCGACCAAGTGACAAAGGGTGTTTCATTTATAGGGATGTTGACGGGA...
Task1_train_48302	Here is a variant on Chromosome 21. Please identify whether it is a benign mutation or associated with a disorder.	Benign	GCTAGATGTGACCAAGAAGAGGGGGTGTAGACCTTCAACTTCCCCGTAACAAAGTAAAACAAGCCCTCCTGGGATTCCTTTCCAGGTGAGAGCAAGTTCCAAACTATTGCTCCCCTCCTCTGCGACCAAGTGACAAAGGGTGTTTCATTTATAGGGATGTTGACGGGAACTGCAAAATAAGCCTGGCACTAGAGAATTGTTTTTCCATTAGTGGTTCTGCAGAATGAAAACCGCTAAGTGAACAAAGTACCAAGTGTGGGACTGAATTGATAGGTGCAGTTTTGTCAACTTAAAAATTCTCTTGGGAAAGAAGCTACAAC...	GCTAGATGTGACCAAGAAGAGGGGGTGTAGACCTTCAACTTCCCCGTAACAAAGTAAAACAAGCCCTCCTGGGATTCCTTTCCAGGTGAGAGCAAGTTCCAAACTATTGCTCCCCTCCTCTGCGACCAAGTGACAAAGGGTGTTTCATTTATAGGGATGTTGACGGGAACTGCAAAATAAGCCTGGCACTAGAGAATTGTTTTTCCATTAGTGGTTCTGCAGAATGAAAACCGCTAAGTGAACAAAGTACCAAGTGTGGGACTGAATTGATAGGTGCAGTTTTGTCAACTTAAAAATTCTCTTGGGAAAGAAGCTACAAC...
Task1_train_48303	A variant found on Chromosome 21 is being studied. Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?	Benign	TCTAGGAGTGGAATTACTGGCCTTTATGGTAAGTGTATGTTTTACTTTGTAAAAAACTGACAAACTTTTCTGAAAATATTGCATTCTTTTTCCTGTGTGCTGGCAGTGGATGAGCGTTACCCTACATCCTTGTCCACACTTGGTGTTGTCAGTCTTTTAAACTGTAGCCATCCTAGTGGATGTGAAGTGACATCTCATTGTGGTTTGAATTTACATTTTCCTGAGGACTACTGATGTGGAGCATCATTTTAAGGACTTTTTGGCCATTTGCCTGTCTTCCTTCTGAAATGTCTTTCAGATCTCTTGTCCATTTTTATTTG...	TCTAGGAGTGGAATTACTGGCCTTTATGGTAAGTGTATGTTTTACTTTGTAAAAAACTGACAAACTTTTCTGAAAATATTGCATTCTTTTTCCTGTGTGCTGGCAGTGGATGAGCGTTACCCTACATCCTTGTCCACACTTGGTGTTGTCAGTCTTTTAAACTGTAGCCATCCTAGTGGATGTGAAGTGACATCTCATTGTGGTTTGAATTTACATTTTCCTGAGGACTACTGATGTGGAGCATCATTTTAAGGACTTTTTGGCCATTTGCCTGTCTTCCTTCTGAAATGTCTTTCAGATCTCTTGTCCATTTTTATTTG...
Task1_train_48304	This mutation is located on Chromosome 21. Is it associated with a disease or is it a benign polymorphism?	Benign	TAAAAGCTCAATGCAATCCCAATCAAAATTATAGCAGTTTAAAAAATACTGGAAAAGCTTTCTAAAATTAATTGAGAACAAGCTAGAACCAACGTTTTTAGAAAATAAGATAGTGGCACCTTCTTTATGAGCTGTTAGGATATATTATGAAGCTGAATAACATGGATAAAACAGCTGGAATGGATGCAAGGATAGATCAAGAGATGAATAGAACAAAATACAAAATAGGGATTTCAGAAGCAGGCTATACAAACATTTCTCAGACAAAAGAGATGTTTCAAATGGGAGATGGAGAGAATAAACTAACTTTAAAAAAGGAC...	TAAAAGCTCAATGCAATCCCAATCAAAATTATAGCAGTTTAAAAAATACTGGAAAAGCTTTCTAAAATTAATTGAGAACAAGCTAGAACCAACGTTTTTAGAAAATAAGATAGTGGCACCTTCTTTATGAGCTGTTAGGATATATTATGAAGCTGAATAACATGGATAAAACAGCTGGAATGGATGCAAGGATAGATCAAGAGATGAATAGAACAAAATACAAAATAGGGATTTCAGAAGCAGGCTATACAAACATTTCTCAGACAAAAGAGATGTTTCAAATGGGAGATGGAGAGAATAAACTAACTTTAAAAAAGGAC...
Task1_train_48305	With a mutation on Chromosome 21, classify this variant as benign or pathogenic. Include the disease if it's pathogenic.	Benign	CACAAGAAAAACACACATAGCCTGATAAGAAATGGGCTAGGAATGTGAACAGGAAACTTTCAGTGTGGACGGCCATGCATTTAGGCCATAGTGGGTTCCCAGCAGCCGTCAGTGCGGAGGGCAGGGAGCTGAGAGCAGATCAGGCTGAGCCGGGGTCACGCGGGGTCCCCCAGCCACTGAGGGCCCTGGGCAGCAACCACGCAGACCCCGCCCCCCAGGCTCCACCTCACTTTCTGTGGCATTTCTGTGCCTGTTCTGACCACAGCCGTGGCAGCACCATGTCCATCAGGCTGCGGCCGGCCTGGCTGTGGGGTGACTGC...	CACAAGAAAAACACACATAGCCTGATAAGAAATGGGCTAGGAATGTGAACAGGAAACTTTCAGTGTGGACGGCCATGCATTTAGGCCATAGTGGGTTCCCAGCAGCCGTCAGTGCGGAGGGCAGGGAGCTGAGAGCAGATCAGGCTGAGCCGGGGTCACGCGGGGTCCCCCAGCCACTGAGGGCCCTGGGCAGCAACCACGCAGACCCCGCCCCCCAGGCTCCACCTCACTTTCTGTGGCATTTCTGTGCCTGTTCTGACCACAGCCGTGGCAGCACCATGTCCATCAGGCTGCGGCCGGCCTGGCTGTGGGGTGACTGC...
Task1_train_48306	Given a variant located on Chromosome 21, assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.	Benign	TGAGTGTGGAAAGGTATATGGTAGAAACACCCACAGAGGTGTTAGAGATAGAACTCAGAGTCGTAAGGAAAACGAGCGCTTAGACAAAGGACTTTTTAGCAAAGCAAATTTATCTTTGCGCAGAGAAGTGCCTCTCACGTGGCCGGTTGCCACGAGAGCACACAGAACAAAGGAGAGTGAAAGTTTTTATTTTTGACGCAAATCCTGCCCCTGTGCCCTTTTTTAACTGGCTGGGGTCGGACCACACAATCTAAGCTAGACCCGATTGGCTAAACATTTAGGGGAAGGGGTCGTCTGCGGCGAGCTAGAGAGTCAGTCTT...	TGAGTGTGGAAAGGTATATGGTAGAAACACCCACAGAGGTGTTAGAGATAGAACTCAGAGTCGTAAGGAAAACGAGCGCTTAGACAAAGGACTTTTTAGCAAAGCAAATTTATCTTTGCGCAGAGAAGTGCCTCTCACGTGGCCGGTTGCCACGAGAGCACACAGAACAAAGGAGAGTGAAAGTTTTTATTTTTGACGCAAATCCTGCCCCTGTGCCCTTTTTTAACTGGCTGGGGTCGGACCACACAATCTAAGCTAGACCCGATTGGCTAAACATTTAGGGGAAGGGGTCGTCTGCGGCGAGCTAGAGAGTCAGTCTT...
Task1_train_48307	Here is a variant on Chromosome 21. Please identify whether it is a benign mutation or associated with a disorder.	Benign	AGTTTTTATTTTTGACGCAAATCCTGCCCCTGTGCCCTTTTTTAACTGGCTGGGGTCGGACCACACAATCTAAGCTAGACCCGATTGGCTAAACATTTAGGGGAAGGGGTCGTCTGCGGCGAGCTAGAGAGTCAGTCTTTTCTCAAATAAGGAAAGGAATGTGAGCTGGTGCTGTGGCATGCCTGGGCGTGTAGGAAAAGCAGAAGGAAAGAAGAAGAAAGACATGGGGAGGGGTACTGGGAATGAAACACTAAAGGACTGATCAGGCTGTTTGAAGAGAAACCTTGCCATATCTCACAAGAGGTATCGTTTGTAATAAT...	AGTTTTTATTTTTGACGCAAATCCTGCCCCTGTGCCCTTTTTTAACTGGCTGGGGTCGGACCACACAATCTAAGCTAGACCCGATTGGCTAAACATTTAGGGGAAGGGGTCGTCTGCGGCGAGCTAGAGAGTCAGTCTTTTCTCAAATAAGGAAAGGAATGTGAGCTGGTGCTGTGGCATGCCTGGGCGTGTAGGAAAAGCAGAAGGAAAGAAGAAGAAAGACATGGGGAGGGGTACTGGGAATGAAACACTAAAGGACTGATCAGGCTGTTTGAAGAGAAACCTTGCCATATCTCACAAGAGGTATCGTTTGTAATAAT...
Task1_train_48308	A variant on Chromosome 21 is under investigation. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.	Benign	TCGTTTGTAATAATGAACAACTGGAGAGACAGTCAGGGCCATCCACCTGGCGTTGCAGACACCAAGTGCGGCGTGTCCACACTTTGGAACGCTGTACACCTTGCTGAAGAAAACCATGAGAAAATAGTTTTTAAAATCAACCCGGACAAAAAAAAGAATAATGTGTGCCCCCCGCATTGTGATTGTATAGCTGTGGAGAAGTAAAGACTCAGGGCCTCTTGCGGGCAACGTGGTGACGGTCATACCTCGCCAGCATCCCTTGCCTGCATTTGCATTTCTAGGAGTCTATTCTCAGATTTGCTCAATCCTGTTTGAAACCA...	TCGTTTGTAATAATGAACAACTGGAGAGACAGTCAGGGCCATCCACCTGGCGTTGCAGACACCAAGTGCGGCGTGTCCACACTTTGGAACGCTGTACACCTTGCTGAAGAAAACCATGAGAAAATAGTTTTTAAAATCAACCCGGACAAAAAAAAGAATAATGTGTGCCCCCCGCATTGTGATTGTATAGCTGTGGAGAAGTAAAGACTCAGGGCCTCTTGCGGGCAACGTGGTGACGGTCATACCTCGCCAGCATCCCTTGCCTGCATTTGCATTTCTAGGAGTCTATTCTCAGATTTGCTCAATCCTGTTTGAAACCA...
Task1_train_48309	Here is a mutation located on Chromosome 21. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?	Benign	CCAGTCTGGGCAACAGAGCCAGACTCCGCCTAAAAAATAATAGAAGTTGCTCCAGGGATTCCAGTTCTGGAAACCTGTTGATGAGATTGTTTGACCCATCATCCTGCTGAAAACAATTGAAAACACTAGGAAGAATCTTCCTAGTTGCAACAGGAAACTGGAAAAGGAATAAAGAATTACAGGATTACAGGCCCAAATCAAAGACAGGGGTCTTTGCCCTTTTTGCACAAGGGAACTTCCCGGCCACCTCGTGAAAGCTTTGGAGGTTTTCAGATAAGTAAAAGGAAACCAACTTCATGAAAACACTGCTGTTACACTAT...	CCAGTCTGGGCAACAGAGCCAGACTCCGCCTAAAAAATAATAGAAGTTGCTCCAGGGATTCCAGTTCTGGAAACCTGTTGATGAGATTGTTTGACCCATCATCCTGCTGAAAACAATTGAAAACACTAGGAAGAATCTTCCTAGTTGCAACAGGAAACTGGAAAAGGAATAAAGAATTACAGGATTACAGGCCCAAATCAAAGACAGGGGTCTTTGCCCTTTTTGCACAAGGGAACTTCCCGGCCACCTCGTGAAAGCTTTGGAGGTTTTCAGATAAGTAAAAGGAAACCAACTTCATGAAAACACTGCTGTTACACTAT...
Task1_train_48310	A variant found on Chromosome 21 is being studied. Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?	Benign	CAGTCTGGGCAACAGAGCCAGACTCCGCCTAAAAAATAATAGAAGTTGCTCCAGGGATTCCAGTTCTGGAAACCTGTTGATGAGATTGTTTGACCCATCATCCTGCTGAAAACAATTGAAAACACTAGGAAGAATCTTCCTAGTTGCAACAGGAAACTGGAAAAGGAATAAAGAATTACAGGATTACAGGCCCAAATCAAAGACAGGGGTCTTTGCCCTTTTTGCACAAGGGAACTTCCCGGCCACCTCGTGAAAGCTTTGGAGGTTTTCAGATAAGTAAAAGGAAACCAACTTCATGAAAACACTGCTGTTACACTATG...	CAGTCTGGGCAACAGAGCCAGACTCCGCCTAAAAAATAATAGAAGTTGCTCCAGGGATTCCAGTTCTGGAAACCTGTTGATGAGATTGTTTGACCCATCATCCTGCTGAAAACAATTGAAAACACTAGGAAGAATCTTCCTAGTTGCAACAGGAAACTGGAAAAGGAATAAAGAATTACAGGATTACAGGCCCAAATCAAAGACAGGGGTCTTTGCCCTTTTTGCACAAGGGAACTTCCCGGCCACCTCGTGAAAGCTTTGGAGGTTTTCAGATAAGTAAAAGGAAACCAACTTCATGAAAACACTGCTGTTACACTATG...
Task1_train_48311	Given this context: Chromosome 21 — does this variant present pathogenic behavior, and if so, what disease does it relate to?	Benign	CAAGTCCACAAGAAACACTTCTGCCGTGCTTGCCTTCCCATCCCGGGTTCTGCTCCCGTGCCCACGTCCTCATCCCAGGTTCTGCCATTGTGTCTGCTTGCTGTGGATTGAATTGTGTCCCTCAAAAGGTGCCGAAGTCCTGACCGCTGGTACATGTGAATGTGACCCTATATGGAAATAGGGTCTTTGTAGGTGATCAAGTTAAGAGGAGGCTGTTAGGATAGGCCCTACTGCAATAATGCTTTGTATCCTTATAAAAAGGGGAGATTTGGACACACACACACACACACACACACACACACACACACACACACACACAC...	CAAGTCCACAAGAAACACTTCTGCCGTGCTTGCCTTCCCATCCCGGGTTCTGCTCCCGTGCCCACGTCCTCATCCCAGGTTCTGCCATTGTGTCTGCTTGCTGTGGATTGAATTGTGTCCCTCAAAAGGTGCCGAAGTCCTGACCGCTGGTACATGTGAATGTGACCCTATATGGAAATAGGGTCTTTGTAGGTGATCAAGTTAAGAGGAGGCTGTTAGGATAGGCCCTACTGCAATAATGCTTTGTATCCTTATAAAAAGGGGAGATTTGGACACACACACACACACACACACACACACACACACACACACACACACAC...
Task1_train_48312	Given this context: Chromosome 21 — does this variant present pathogenic behavior, and if so, what disease does it relate to?	Benign	AATGCCAATCTAACCCAAACTTTTCCAGAAAACCGTGGGGTAGACACAGTGTCGGCGAGGGTGCTAGGGATTAGGGGACGGAGGCTGAGGCCTCACGGGTGGCAGGGATGCCCTTGGTGGGCTCTGGCCATGGACACAGACTCCTGGGATGAGAGGGGGACTCATGGAGGAACACCCACGCCTTGACCCTGAGATGGCCTTGCAGGGAGGGTAACTGAAAATTTACCCACTGGGGACAGTTGCCTACTTACTAAAACAGTTCCAGCCACCACCGCAGCCCCTGGAAGGCCATCCCCCCAGAAAATCCCCCAGGTCTCAGC...	AATGCCAATCTAACCCAAACTTTTCCAGAAAACCGTGGGGTAGACACAGTGTCGGCGAGGGTGCTAGGGATTAGGGGACGGAGGCTGAGGCCTCACGGGTGGCAGGGATGCCCTTGGTGGGCTCTGGCCATGGACACAGACTCCTGGGATGAGAGGGGGACTCATGGAGGAACACCCACGCCTTGACCCTGAGATGGCCTTGCAGGGAGGGTAACTGAAAATTTACCCACTGGGGACAGTTGCCTACTTACTAAAACAGTTCCAGCCACCACCGCAGCCCCTGGAAGGCCATCCCCCCAGAAAATCCCCCAGGTCTCAGC...
Task1_train_48313	This mutation occurs on Chromosome 21. Does this change lead to a known medical condition, or is it benign?	Benign	GTGAGTGACCATTTTGAGGGACGGTTTTCCAAGGTGCTTTCACTAGGAGTTGAAGCTCTGATGAAGCAGAAGACACATCGAATGAGGACCCAGAGCAGGGGTCAGAGGTGAGACCCCCCCACCAGGAGATGTCCTCCCTGGGGATGGCCAGACAGGCTGGGTCCTGTCGGTGCCTCGGACGAGGGCAGGTGGGGACAATGACAAACATGGAGGAGGTCAGAGAGCCAGCCCCGGCCCCTCCACCTGGCTCTCTGTTCTGACCTTGTAGCCATCAGTGGGCATAGTGAGGTGGGTGGGGCTCAGACACGCATGTGTGGGGA...	GTGAGTGACCATTTTGAGGGACGGTTTTCCAAGGTGCTTTCACTAGGAGTTGAAGCTCTGATGAAGCAGAAGACACATCGAATGAGGACCCAGAGCAGGGGTCAGAGGTGAGACCCCCCCACCAGGAGATGTCCTCCCTGGGGATGGCCAGACAGGCTGGGTCCTGTCGGTGCCTCGGACGAGGGCAGGTGGGGACAATGACAAACATGGAGGAGGTCAGAGAGCCAGCCCCGGCCCCTCCACCTGGCTCTCTGTTCTGACCTTGTAGCCATCAGTGGGCATAGTGAGGTGGGTGGGGCTCAGACACGCATGTGTGGGGA...
Task1_train_48314	Chromosome 21 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	TTCACCTTTGAACAATGTTCTTCCTGGTCTAGAATTCTAGGTTTGCAGTGATTTTCTTTCAGCTCTTTAAAGATGTCATTCTATTACCTTTAGTTTCTTCAACAGCTCTTTTAGGAGAGCTTTAAAGGAATCATTTTTAAAACATTTTGTTCAGCTTTTCAAGTTGTTCTCAGCAGGAGTATATGTCTGACATAGCTACTTTGTCCCATATGGAAGCAGAGGCCCCCATTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCCTTCCATCCCATAGGACCAGATCCTGTACCTCTGGAGGGACCAGGCCATGC...	TTCACCTTTGAACAATGTTCTTCCTGGTCTAGAATTCTAGGTTTGCAGTGATTTTCTTTCAGCTCTTTAAAGATGTCATTCTATTACCTTTAGTTTCTTCAACAGCTCTTTTAGGAGAGCTTTAAAGGAATCATTTTTAAAACATTTTGTTCAGCTTTTCAAGTTGTTCTCAGCAGGAGTATATGTCTGACATAGCTACTTTGTCCCATATGGAAGCAGAGGCCCCCATTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCCTTCCATCCCATAGGACCAGATCCTGTACCTCTGGAGGGACCAGGCCATGC...
Task1_train_48315	Here is a variant on Chromosome 21. Please identify whether it is a benign mutation or associated with a disorder.	Benign	GGCCCCTGGAGCCCTCTCCCCTGGGTAGGGGCCACTTCTCAGGGCCGCATGCATGCTGGGCTATGGCTGGTCATCACTGACATCACCAGGCACCAAGCAGCCCACCTCCCTCCCTGGTGGGGTCCACAGTCAGGGTTACTACCCCTTCACTTTCACATTCTCAGCACCTGGTGCAATTTCCAGCATGTGGGAGGACTCACTGCATCATGAATAAATGAATGCTTGAGAAGTAAAAGTATCGGATACAATTGGAAACATTTAGCAGAAACAACCAAAAAGATGTGGTGGCCAATTGGATATTATTTGCAGAAGAAATGGAG...	GGCCCCTGGAGCCCTCTCCCCTGGGTAGGGGCCACTTCTCAGGGCCGCATGCATGCTGGGCTATGGCTGGTCATCACTGACATCACCAGGCACCAAGCAGCCCACCTCCCTCCCTGGTGGGGTCCACAGTCAGGGTTACTACCCCTTCACTTTCACATTCTCAGCACCTGGTGCAATTTCCAGCATGTGGGAGGACTCACTGCATCATGAATAAATGAATGCTTGAGAAGTAAAAGTATCGGATACAATTGGAAACATTTAGCAGAAACAACCAAAAAGATGTGGTGGCCAATTGGATATTATTTGCAGAAGAAATGGAG...
Task1_train_48316	This genomic variant is located on Chromosome 21. Can you determine its pathogenicity and name any linked disease?	Benign	CCTCCCTCCCTGGTGGGGTCCACAGTCAGGGTTACTACCCCTTCACTTTCACATTCTCAGCACCTGGTGCAATTTCCAGCATGTGGGAGGACTCACTGCATCATGAATAAATGAATGCTTGAGAAGTAAAAGTATCGGATACAATTGGAAACATTTAGCAGAAACAACCAAAAAGATGTGGTGGCCAATTGGATATTATTTGCAGAAGAAATGGAGACTTAGATCAGATGTCTAGCTGGGGTGACCAAGGACTTAGCTGGCAATCAAGAAAACACACTGCAAGCGAAAGCAGTGCTTGCTGCTTTTCACACGGCAGTGCT...	CCTCCCTCCCTGGTGGGGTCCACAGTCAGGGTTACTACCCCTTCACTTTCACATTCTCAGCACCTGGTGCAATTTCCAGCATGTGGGAGGACTCACTGCATCATGAATAAATGAATGCTTGAGAAGTAAAAGTATCGGATACAATTGGAAACATTTAGCAGAAACAACCAAAAAGATGTGGTGGCCAATTGGATATTATTTGCAGAAGAAATGGAGACTTAGATCAGATGTCTAGCTGGGGTGACCAAGGACTTAGCTGGCAATCAAGAAAACACACTGCAAGCGAAAGCAGTGCTTGCTGCTTTTCACACGGCAGTGCT...
Task1_train_48317	A mutation on Chromosome 21 is under review. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.	Benign	AGGAGTTCAAGACCAGCTGGGCAACATAGCAAGACTCTGGTCTCTACAAAAAAAATTTTTTTTTACAAAAAGAAATATTGATAATGGGACTTGAATTATCTATGATTGAAGCGTATCATAAAGCTATGGCCTGAAAGAGCAGAACCAAATCCATAGCCCAAAATGGACCAGTTCAAAACTTTTCTATCCTGTCTGAAACCCAGTCCTATCCCCAGCGTTCCCACATGCAAGTCTGAGTGGACCTCGGGGAAGGCCGCGGGGAGCGGCATGGCCTCTCTTTCCTTGCTCCCCTTCTCCCTGTTTTGGGCTCTAATTTCTTC...	AGGAGTTCAAGACCAGCTGGGCAACATAGCAAGACTCTGGTCTCTACAAAAAAAATTTTTTTTTACAAAAAGAAATATTGATAATGGGACTTGAATTATCTATGATTGAAGCGTATCATAAAGCTATGGCCTGAAAGAGCAGAACCAAATCCATAGCCCAAAATGGACCAGTTCAAAACTTTTCTATCCTGTCTGAAACCCAGTCCTATCCCCAGCGTTCCCACATGCAAGTCTGAGTGGACCTCGGGGAAGGCCGCGGGGAGCGGCATGGCCTCTCTTTCCTTGCTCCCCTTCTCCCTGTTTTGGGCTCTAATTTCTTC...
Task1_train_48318	A genomic variant on Chromosome 21 is under review. What is the biological outcome — benign or pathogenic?	Benign	GTGGCGTGTCCCTTTGATGGAATATGATTCAGCCAAGAAAAGGAATGGCGTTCTGAAACATACCCAAACACAGGTGTACCTTGAAAACATGCTGAGTGAACAAAGCTAGACACAAAGACCACATATTCCATGACTGCGTCTATATGAAATGTGCAGAACAGGCAAATCCATAGAGACAAGCAGAATAGTATTGGTTGCCAGGGGCTGGGCATGGCTGCTTAATAGTACCGGGGTTCCTTCGGGAGCGATGATAGTATTCTGGAACTAGGTAGTGGGGATGGTTGCACAACATTATGACTGTACTGTCACTGAATTGCACA...	GTGGCGTGTCCCTTTGATGGAATATGATTCAGCCAAGAAAAGGAATGGCGTTCTGAAACATACCCAAACACAGGTGTACCTTGAAAACATGCTGAGTGAACAAAGCTAGACACAAAGACCACATATTCCATGACTGCGTCTATATGAAATGTGCAGAACAGGCAAATCCATAGAGACAAGCAGAATAGTATTGGTTGCCAGGGGCTGGGCATGGCTGCTTAATAGTACCGGGGTTCCTTCGGGAGCGATGATAGTATTCTGGAACTAGGTAGTGGGGATGGTTGCACAACATTATGACTGTACTGTCACTGAATTGCACA...
Task1_train_48319	A variant was discovered on Chromosome 21. What is its functional impact — neutral or pathogenic? State the disease if pathogenic.	Benign	GACTGCGTCTATATGAAATGTGCAGAACAGGCAAATCCATAGAGACAAGCAGAATAGTATTGGTTGCCAGGGGCTGGGCATGGCTGCTTAATAGTACCGGGGTTCCTTCGGGAGCGATGATAGTATTCTGGAACTAGGTAGTGGGGATGGTTGCACAACATTATGACTGTACTGTCACTGAATTGCACACTTTAAAATGGGTAAAATGGTACATTTTATTTTATGGTTGATCACAATTTAAATAAAATTACACCTGCCAAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATC...	GACTGCGTCTATATGAAATGTGCAGAACAGGCAAATCCATAGAGACAAGCAGAATAGTATTGGTTGCCAGGGGCTGGGCATGGCTGCTTAATAGTACCGGGGTTCCTTCGGGAGCGATGATAGTATTCTGGAACTAGGTAGTGGGGATGGTTGCACAACATTATGACTGTACTGTCACTGAATTGCACACTTTAAAATGGGTAAAATGGTACATTTTATTTTATGGTTGATCACAATTTAAATAAAATTACACCTGCCAAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATC...
Task1_train_48320	Chromosome 21 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	AGACAAGCAGAATAGTATTGGTTGCCAGGGGCTGGGCATGGCTGCTTAATAGTACCGGGGTTCCTTCGGGAGCGATGATAGTATTCTGGAACTAGGTAGTGGGGATGGTTGCACAACATTATGACTGTACTGTCACTGAATTGCACACTTTAAAATGGGTAAAATGGTACATTTTATTTTATGGTTGATCACAATTTAAATAAAATTACACCTGCCAAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATCTTGTTTGCTCTTACAGGTGGGAGACGTGTGTTTAAACCTGAG...	AGACAAGCAGAATAGTATTGGTTGCCAGGGGCTGGGCATGGCTGCTTAATAGTACCGGGGTTCCTTCGGGAGCGATGATAGTATTCTGGAACTAGGTAGTGGGGATGGTTGCACAACATTATGACTGTACTGTCACTGAATTGCACACTTTAAAATGGGTAAAATGGTACATTTTATTTTATGGTTGATCACAATTTAAATAAAATTACACCTGCCAAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATCTTGTTTGCTCTTACAGGTGGGAGACGTGTGTTTAAACCTGAG...
Task1_train_48321	This alteration on Chromosome 21 may affect genome function. Does it lead to a disease or is it benign?	Benign	TGACTGTACTGTCACTGAATTGCACACTTTAAAATGGGTAAAATGGTACATTTTATTTTATGGTTGATCACAATTTAAATAAAATTACACCTGCCAAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATCTTGTTTGCTCTTACAGGTGGGAGACGTGTGTTTAAACCTGAGAAACTTTAGTTATTAATGAGATCAACTAGCTGTTCATCTCATTCATGCTTATTGGAAATTTAAAATTTTTAGTCTTCTATTCATTTCTTTTGTATCTTATCCTGTTTTAGTGGTAAGGACT...	TGACTGTACTGTCACTGAATTGCACACTTTAAAATGGGTAAAATGGTACATTTTATTTTATGGTTGATCACAATTTAAATAAAATTACACCTGCCAAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATCTTGTTTGCTCTTACAGGTGGGAGACGTGTGTTTAAACCTGAGAAACTTTAGTTATTAATGAGATCAACTAGCTGTTCATCTCATTCATGCTTATTGGAAATTTAAAATTTTTAGTCTTCTATTCATTTCTTTTGTATCTTATCCTGTTTTAGTGGTAAGGACT...
Task1_train_48322	This alteration occurs on Chromosome 21. Is it associated with a disease or is it a benign variant?	Benign	AAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATCTTGTTTGCTCTTACAGGTGGGAGACGTGTGTTTAAACCTGAGAAACTTTAGTTATTAATGAGATCAACTAGCTGTTCATCTCATTCATGCTTATTGGAAATTTAAAATTTTTAGTCTTCTATTCATTTCTTTTGTATCTTATCCTGTTTTAGTGGTAAGGACTTCAAATTTTTCACATTAATCTTCCACCTGTCATGGAGATTACAAGTACTTTCTGGCAGTTCATATCTTCATTTGTGTACCCAATGATTCCTTCAG...	AAGGGTTTCTAAGAATGAAGCCCCTCGCTCTGCAATGCTGGATATTATCAGCATTTTAAATCTTGTTTGCTCTTACAGGTGGGAGACGTGTGTTTAAACCTGAGAAACTTTAGTTATTAATGAGATCAACTAGCTGTTCATCTCATTCATGCTTATTGGAAATTTAAAATTTTTAGTCTTCTATTCATTTCTTTTGTATCTTATCCTGTTTTAGTGGTAAGGACTTCAAATTTTTCACATTAATCTTCCACCTGTCATGGAGATTACAAGTACTTTCTGGCAGTTCATATCTTCATTTGTGTACCCAATGATTCCTTCAG...
Task1_train_48323	This variant lies on Chromosome 21. Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?	Benign	CACTTCGGAGATAAGTCTTTATATTGAAAGGCTCAATAAGTTCTAACCACTGAAAGTAAAATAATGCATTAGCCTAGAAACAAAAGCGTGACACTTTAGAACAATAAAAAGAAACCCAAATGCTCCCAGAGAGTTAAGGAAAGAGAGAAACTAAAAAATGACAAATGACCAGTATCAGACTGTCATCGGCAACACTGGACATCACAAAAAAATGGTGACATGTGTTCATCATTTTGAGGAAAAGTAATTTAAAACCAGAATTTTATACCCAGCTAAACTATCATTATAAATGTGAGGATAAAGTTGACATATTTTCAGAC...	CACTTCGGAGATAAGTCTTTATATTGAAAGGCTCAATAAGTTCTAACCACTGAAAGTAAAATAATGCATTAGCCTAGAAACAAAAGCGTGACACTTTAGAACAATAAAAAGAAACCCAAATGCTCCCAGAGAGTTAAGGAAAGAGAGAAACTAAAAAATGACAAATGACCAGTATCAGACTGTCATCGGCAACACTGGACATCACAAAAAAATGGTGACATGTGTTCATCATTTTGAGGAAAAGTAATTTAAAACCAGAATTTTATACCCAGCTAAACTATCATTATAAATGTGAGGATAAAGTTGACATATTTTCAGAC...
Task1_train_48324	This mutation is located on Chromosome 21. Is it associated with a disease or is it a benign polymorphism?	Benign	GAGCTGTGGACAGAACTTAGAAGTCTATGGACCCAGAGCCGATCTGTGGCCATGTGGGAGTCACCTTAAGGCCTAGGGACAAGCCGGGCGAGGCCACAAGTTCACAGGCAACTCCTTTCACTGCTATAGTTCAGAATCACACTTAAAAACCAAGAGAATTGGGGCAGCCACAGTGATTGTGAGCTAGTCACCAAGTAATCCATTTTAAAAGTTGGTTGTCTTACGAGTCGATTACAGAAGAACAAGGATGCGTCTTTGATATTTATCTGCTCCTTTACCTTCCCCTGTTCCTCCTACTCCTTCCTGCAGGTCAGGGCCCA...	GAGCTGTGGACAGAACTTAGAAGTCTATGGACCCAGAGCCGATCTGTGGCCATGTGGGAGTCACCTTAAGGCCTAGGGACAAGCCGGGCGAGGCCACAAGTTCACAGGCAACTCCTTTCACTGCTATAGTTCAGAATCACACTTAAAAACCAAGAGAATTGGGGCAGCCACAGTGATTGTGAGCTAGTCACCAAGTAATCCATTTTAAAAGTTGGTTGTCTTACGAGTCGATTACAGAAGAACAAGGATGCGTCTTTGATATTTATCTGCTCCTTTACCTTCCCCTGTTCCTCCTACTCCTTCCTGCAGGTCAGGGCCCA...
Task1_train_48325	A genomic variant on Chromosome 21 is under review. What is the biological outcome — benign or pathogenic?	Benign	TAAATAGACCATGTTATGGATTGCTGGATATGTCGACTCTCCCCAAATTGATCTATATAGTTTCAATACACTCCCAATCAAAATCTCAGCACAAATTCTGTAGATATTGATAAGCTTATTCAAATATCTATATGGAAAGACAAAGAAACTAGAGTAGCCTAAACAACTTCTTAAAAGAAGAACAAAATTGGAGAACTCACACTAGCTGATTTCAAGACCTACTATAAAGCTGCATTTATCAGGGCAGGATGGTGTTGGCAAAAAGATACTTAGCATATGACCCAGCTATTCCACTCCTAGACATTTACCCAAGAGAAAGA...	TAAATAGACCATGTTATGGATTGCTGGATATGTCGACTCTCCCCAAATTGATCTATATAGTTTCAATACACTCCCAATCAAAATCTCAGCACAAATTCTGTAGATATTGATAAGCTTATTCAAATATCTATATGGAAAGACAAAGAAACTAGAGTAGCCTAAACAACTTCTTAAAAGAAGAACAAAATTGGAGAACTCACACTAGCTGATTTCAAGACCTACTATAAAGCTGCATTTATCAGGGCAGGATGGTGTTGGCAAAAAGATACTTAGCATATGACCCAGCTATTCCACTCCTAGACATTTACCCAAGAGAAAGA...
Task1_train_48326	This mutation on Chromosome 21 may be significant. Is it associated with any clinical condition, or is it benign?	Benign	ATCTATATAGTTTCAATACACTCCCAATCAAAATCTCAGCACAAATTCTGTAGATATTGATAAGCTTATTCAAATATCTATATGGAAAGACAAAGAAACTAGAGTAGCCTAAACAACTTCTTAAAAGAAGAACAAAATTGGAGAACTCACACTAGCTGATTTCAAGACCTACTATAAAGCTGCATTTATCAGGGCAGGATGGTGTTGGCAAAAAGATACTTAGCATATGACCCAGCTATTCCACTCCTAGACATTTACCCAAGAGAAAGAAACAAATACGTCCATGCAAAAACCTGGACTTGCTAACAAATGCCCCATGT...	ATCTATATAGTTTCAATACACTCCCAATCAAAATCTCAGCACAAATTCTGTAGATATTGATAAGCTTATTCAAATATCTATATGGAAAGACAAAGAAACTAGAGTAGCCTAAACAACTTCTTAAAAGAAGAACAAAATTGGAGAACTCACACTAGCTGATTTCAAGACCTACTATAAAGCTGCATTTATCAGGGCAGGATGGTGTTGGCAAAAAGATACTTAGCATATGACCCAGCTATTCCACTCCTAGACATTTACCCAAGAGAAAGAAACAAATACGTCCATGCAAAAACCTGGACTTGCTAACAAATGCCCCATGT...
Task1_train_48327	This sequence variant lies on Chromosome 21. Is it clinically significant, and what condition might it cause if any?	Benign	GAGAAAGAAACAAATACGTCCATGCAAAAACCTGGACTTGCTAACAAATGCCCCATGTGGAGCACTAGCATCACAGAACTTGGGCTCCAAGTGGCCCTGAGGGCCACAGCTCCAGAGGGCGGGGGCTGAGCCAGGCCTCATCCATGCTTCTCTGTGCACAGGGCAGGTAGGTTCTCCAGAAGCATTTTTTGGTTACCAACCCTCCCTCCTCTCATGCTCTGATTTCCAGTTTGACCTCTAACTCCCAGCCTGGGGGACCAGAGTGCTTACGTGTGTGCATAAGTGTGTGCACGTTGTATAGTGCACACATTGGGTGTGTT...	GAGAAAGAAACAAATACGTCCATGCAAAAACCTGGACTTGCTAACAAATGCCCCATGTGGAGCACTAGCATCACAGAACTTGGGCTCCAAGTGGCCCTGAGGGCCACAGCTCCAGAGGGCGGGGGCTGAGCCAGGCCTCATCCATGCTTCTCTGTGCACAGGGCAGGTAGGTTCTCCAGAAGCATTTTTTGGTTACCAACCCTCCCTCCTCTCATGCTCTGATTTCCAGTTTGACCTCTAACTCCCAGCCTGGGGGACCAGAGTGCTTACGTGTGTGCATAAGTGTGTGCACGTTGTATAGTGCACACATTGGGTGTGTT...
Task1_train_48328	A mutation found on Chromosome 21 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	TGCTAACAAATGCCCCATGTGGAGCACTAGCATCACAGAACTTGGGCTCCAAGTGGCCCTGAGGGCCACAGCTCCAGAGGGCGGGGGCTGAGCCAGGCCTCATCCATGCTTCTCTGTGCACAGGGCAGGTAGGTTCTCCAGAAGCATTTTTTGGTTACCAACCCTCCCTCCTCTCATGCTCTGATTTCCAGTTTGACCTCTAACTCCCAGCCTGGGGGACCAGAGTGCTTACGTGTGTGCATAAGTGTGTGCACGTTGTATAGTGCACACATTGGGTGTGTTCATGGATTCGAATGTGTTCGGCTGCAAGCATTTATATG...	TGCTAACAAATGCCCCATGTGGAGCACTAGCATCACAGAACTTGGGCTCCAAGTGGCCCTGAGGGCCACAGCTCCAGAGGGCGGGGGCTGAGCCAGGCCTCATCCATGCTTCTCTGTGCACAGGGCAGGTAGGTTCTCCAGAAGCATTTTTTGGTTACCAACCCTCCCTCCTCTCATGCTCTGATTTCCAGTTTGACCTCTAACTCCCAGCCTGGGGGACCAGAGTGCTTACGTGTGTGCATAAGTGTGTGCACGTTGTATAGTGCACACATTGGGTGTGTTCATGGATTCGAATGTGTTCGGCTGCAAGCATTTATATG...
Task1_train_48329	A genomic change on Chromosome 21 is noted. Classify this variant as benign or pathogenic, and name the disease if relevant.	Benign	GCTAACAAATGCCCCATGTGGAGCACTAGCATCACAGAACTTGGGCTCCAAGTGGCCCTGAGGGCCACAGCTCCAGAGGGCGGGGGCTGAGCCAGGCCTCATCCATGCTTCTCTGTGCACAGGGCAGGTAGGTTCTCCAGAAGCATTTTTTGGTTACCAACCCTCCCTCCTCTCATGCTCTGATTTCCAGTTTGACCTCTAACTCCCAGCCTGGGGGACCAGAGTGCTTACGTGTGTGCATAAGTGTGTGCACGTTGTATAGTGCACACATTGGGTGTGTTCATGGATTCGAATGTGTTCGGCTGCAAGCATTTATATGT...	GCTAACAAATGCCCCATGTGGAGCACTAGCATCACAGAACTTGGGCTCCAAGTGGCCCTGAGGGCCACAGCTCCAGAGGGCGGGGGCTGAGCCAGGCCTCATCCATGCTTCTCTGTGCACAGGGCAGGTAGGTTCTCCAGAAGCATTTTTTGGTTACCAACCCTCCCTCCTCTCATGCTCTGATTTCCAGTTTGACCTCTAACTCCCAGCCTGGGGGACCAGAGTGCTTACGTGTGTGCATAAGTGTGTGCACGTTGTATAGTGCACACATTGGGTGTGTTCATGGATTCGAATGTGTTCGGCTGCAAGCATTTATATGT...
Task1_train_48330	A variant was discovered on Chromosome 21. Please indicate if this mutation results in a known disease or if it's non-harmful.	Benign	GGCAAACAGTTTATGGCTAAGACTACAAAAACACAGGCAACAAAAACCAAAATAGACAAATGAGATTATATTAAACTGAAAAGCTCTGCACAGCAAACGGAACAATCAACAGAGTGAAGAGACAACCTGTGTAATGGGAGAAAATATTTGTAAACTATGCATCTGACAAGTGACTAATATCCAGAATATGTAAGGAACTCAAACAACTCAACAACAACAACAAAACAAATAATTCCATTAATAAATGGGCAAAGCACCTGAATAGGCATCTCTCAAAAGAAGACATACAAATGGCCAACAGGTATATTAAAAAAAACTCA...	GGCAAACAGTTTATGGCTAAGACTACAAAAACACAGGCAACAAAAACCAAAATAGACAAATGAGATTATATTAAACTGAAAAGCTCTGCACAGCAAACGGAACAATCAACAGAGTGAAGAGACAACCTGTGTAATGGGAGAAAATATTTGTAAACTATGCATCTGACAAGTGACTAATATCCAGAATATGTAAGGAACTCAAACAACTCAACAACAACAACAAAACAAATAATTCCATTAATAAATGGGCAAAGCACCTGAATAGGCATCTCTCAAAAGAAGACATACAAATGGCCAACAGGTATATTAAAAAAAACTCA...
Task1_train_48331	Given a variant located on Chromosome 21, assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.	Benign	GACAAATGAGATTATATTAAACTGAAAAGCTCTGCACAGCAAACGGAACAATCAACAGAGTGAAGAGACAACCTGTGTAATGGGAGAAAATATTTGTAAACTATGCATCTGACAAGTGACTAATATCCAGAATATGTAAGGAACTCAAACAACTCAACAACAACAACAAAACAAATAATTCCATTAATAAATGGGCAAAGCACCTGAATAGGCATCTCTCAAAAGAAGACATACAAATGGCCAACAGGTATATTAAAAAAAACTCAACATCACTAATCATCAGGGAACTTCAGATCAAAACTACAATGAGATAGCATCAT...	GACAAATGAGATTATATTAAACTGAAAAGCTCTGCACAGCAAACGGAACAATCAACAGAGTGAAGAGACAACCTGTGTAATGGGAGAAAATATTTGTAAACTATGCATCTGACAAGTGACTAATATCCAGAATATGTAAGGAACTCAAACAACTCAACAACAACAACAAAACAAATAATTCCATTAATAAATGGGCAAAGCACCTGAATAGGCATCTCTCAAAAGAAGACATACAAATGGCCAACAGGTATATTAAAAAAAACTCAACATCACTAATCATCAGGGAACTTCAGATCAAAACTACAATGAGATAGCATCAT...
Task1_train_48332	A variant on Chromosome 21 has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?	Benign	TTTTCACTTCAAGGGGCCCATCCACCACACACCTCGAGCCCTCACCTGCTGGTCACTGCCTGTGGGCCTGAAGCCCTCCAACTTTCCAGGCAGAGCCAAGCAGCTCTCCCTTAATCTCAGGATCCTCCAGGCTAGATGAGCCCTGGGGCTCTAGAGTCCTCAACCACAAAGGCTGCCGAATGTCTTCTTCTCAAAATTAAAAACAATTCACTTCCCATAAAGAAATCTTTCAACCTCCTAGAACAACCCCTCTGAACTCTGAACTGGACCTTCCCTTCACAATAATGTTTTTTCACATTCCCACTCATAAATAAACCCAA...	TTTTCACTTCAAGGGGCCCATCCACCACACACCTCGAGCCCTCACCTGCTGGTCACTGCCTGTGGGCCTGAAGCCCTCCAACTTTCCAGGCAGAGCCAAGCAGCTCTCCCTTAATCTCAGGATCCTCCAGGCTAGATGAGCCCTGGGGCTCTAGAGTCCTCAACCACAAAGGCTGCCGAATGTCTTCTTCTCAAAATTAAAAACAATTCACTTCCCATAAAGAAATCTTTCAACCTCCTAGAACAACCCCTCTGAACTCTGAACTGGACCTTCCCTTCACAATAATGTTTTTTCACATTCCCACTCATAAATAAACCCAA...
Task1_train_48333	This sequence change occurs on Chromosome 21. What is the medical significance of this variant — is it benign or linked to a disease?	Benign	CCTCGAGCCCTCACCTGCTGGTCACTGCCTGTGGGCCTGAAGCCCTCCAACTTTCCAGGCAGAGCCAAGCAGCTCTCCCTTAATCTCAGGATCCTCCAGGCTAGATGAGCCCTGGGGCTCTAGAGTCCTCAACCACAAAGGCTGCCGAATGTCTTCTTCTCAAAATTAAAAACAATTCACTTCCCATAAAGAAATCTTTCAACCTCCTAGAACAACCCCTCTGAACTCTGAACTGGACCTTCCCTTCACAATAATGTTTTTTCACATTCCCACTCATAAATAAACCCAAATCCTCTCTCTTTAGATGGAAGGAGCTCCTT...	CCTCGAGCCCTCACCTGCTGGTCACTGCCTGTGGGCCTGAAGCCCTCCAACTTTCCAGGCAGAGCCAAGCAGCTCTCCCTTAATCTCAGGATCCTCCAGGCTAGATGAGCCCTGGGGCTCTAGAGTCCTCAACCACAAAGGCTGCCGAATGTCTTCTTCTCAAAATTAAAAACAATTCACTTCCCATAAAGAAATCTTTCAACCTCCTAGAACAACCCCTCTGAACTCTGAACTGGACCTTCCCTTCACAATAATGTTTTTTCACATTCCCACTCATAAATAAACCCAAATCCTCTCTCTTTAGATGGAAGGAGCTCCTT...
Task1_train_48334	Chromosome 21 houses a mutation. Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?	Benign	TTTCCTGAATAAAAATAAACGTCCAGACCCATAAAGTGCCCAGCAGCATGAGTGAGAAAATCACCCACCTCTGAGGCACATAAGGAAACACTGAATGCCAGAATATGGTCCCAGATACTTCCAGGGAAAAACCAAGTTACAAACAAAGCACAGAGAATCAGAATCCACTGAACTTCTCACCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGCAGTGATATGACCTCAGCTCCCTGCAGCCTCCACCTCCTGGGCTCAAACAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGG...	TTTCCTGAATAAAAATAAACGTCCAGACCCATAAAGTGCCCAGCAGCATGAGTGAGAAAATCACCCACCTCTGAGGCACATAAGGAAACACTGAATGCCAGAATATGGTCCCAGATACTTCCAGGGAAAAACCAAGTTACAAACAAAGCACAGAGAATCAGAATCCACTGAACTTCTCACCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGCAGTGATATGACCTCAGCTCCCTGCAGCCTCCACCTCCTGGGCTCAAACAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGG...
Task1_train_48335	Chromosome 21 houses a mutation. Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?	Benign	CCCATAAAGTGCCCAGCAGCATGAGTGAGAAAATCACCCACCTCTGAGGCACATAAGGAAACACTGAATGCCAGAATATGGTCCCAGATACTTCCAGGGAAAAACCAAGTTACAAACAAAGCACAGAGAATCAGAATCCACTGAACTTCTCACCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGCAGTGATATGACCTCAGCTCCCTGCAGCCTCCACCTCCTGGGCTCAAACAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGCTTGCACCACCACACCTGG...	CCCATAAAGTGCCCAGCAGCATGAGTGAGAAAATCACCCACCTCTGAGGCACATAAGGAAACACTGAATGCCAGAATATGGTCCCAGATACTTCCAGGGAAAAACCAAGTTACAAACAAAGCACAGAGAATCAGAATCCACTGAACTTCTCACCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGCAGTGATATGACCTCAGCTCCCTGCAGCCTCCACCTCCTGGGCTCAAACAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGCTTGCACCACCACACCTGG...
Task1_train_48336	A variant on Chromosome 21 is under investigation. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.	Benign	ATAAAGTGCCCAGCAGCATGAGTGAGAAAATCACCCACCTCTGAGGCACATAAGGAAACACTGAATGCCAGAATATGGTCCCAGATACTTCCAGGGAAAAACCAAGTTACAAACAAAGCACAGAGAATCAGAATCCACTGAACTTCTCACCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGCAGTGATATGACCTCAGCTCCCTGCAGCCTCCACCTCCTGGGCTCAAACAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGCTTGCACCACCACACCTGGCTA...	ATAAAGTGCCCAGCAGCATGAGTGAGAAAATCACCCACCTCTGAGGCACATAAGGAAACACTGAATGCCAGAATATGGTCCCAGATACTTCCAGGGAAAAACCAAGTTACAAACAAAGCACAGAGAATCAGAATCCACTGAACTTCTCACCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGCAGTGATATGACCTCAGCTCCCTGCAGCCTCCACCTCCTGGGCTCAAACAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGCTTGCACCACCACACCTGGCTA...
Task1_train_48337	A mutation on Chromosome 21 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	TCAGAGGCCCACTTTACCCAAAAAAGCCTACCTGCCTCCCAGCATTCCAAGCGGTCATGTCGACACCACTGAGATGGAACACAGGAACACGCAGCATACTAAACACACGCAGGTAGTAAACCGTTTTATTGGAAACTGGTTAAAAATTAAGGCACTCCAAGCTTTATGGTTTCCTTGAGGTTACAGTTTTGTGGCTGCTCTTAGTGTATTTCAGAAAAAAGCAGATGGACGAAGACCGACCTTACAGACGTGGGTTTCTACACTGAGCGCAAGGGCTGACTACGCTGTATTTCACAACCGAGCCCTAGCGCCAGCTCAGC...	TCAGAGGCCCACTTTACCCAAAAAAGCCTACCTGCCTCCCAGCATTCCAAGCGGTCATGTCGACACCACTGAGATGGAACACAGGAACACGCAGCATACTAAACACACGCAGGTAGTAAACCGTTTTATTGGAAACTGGTTAAAAATTAAGGCACTCCAAGCTTTATGGTTTCCTTGAGGTTACAGTTTTGTGGCTGCTCTTAGTGTATTTCAGAAAAAAGCAGATGGACGAAGACCGACCTTACAGACGTGGGTTTCTACACTGAGCGCAAGGGCTGACTACGCTGTATTTCACAACCGAGCCCTAGCGCCAGCTCAGC...
Task1_train_48338	This genomic variant is located on Chromosome 21. Can you determine its pathogenicity and name any linked disease?	Benign	CCACTTTACCCAAAAAAGCCTACCTGCCTCCCAGCATTCCAAGCGGTCATGTCGACACCACTGAGATGGAACACAGGAACACGCAGCATACTAAACACACGCAGGTAGTAAACCGTTTTATTGGAAACTGGTTAAAAATTAAGGCACTCCAAGCTTTATGGTTTCCTTGAGGTTACAGTTTTGTGGCTGCTCTTAGTGTATTTCAGAAAAAAGCAGATGGACGAAGACCGACCTTACAGACGTGGGTTTCTACACTGAGCGCAAGGGCTGACTACGCTGTATTTCACAACCGAGCCCTAGCGCCAGCTCAGCACCCTACG...	CCACTTTACCCAAAAAAGCCTACCTGCCTCCCAGCATTCCAAGCGGTCATGTCGACACCACTGAGATGGAACACAGGAACACGCAGCATACTAAACACACGCAGGTAGTAAACCGTTTTATTGGAAACTGGTTAAAAATTAAGGCACTCCAAGCTTTATGGTTTCCTTGAGGTTACAGTTTTGTGGCTGCTCTTAGTGTATTTCAGAAAAAAGCAGATGGACGAAGACCGACCTTACAGACGTGGGTTTCTACACTGAGCGCAAGGGCTGACTACGCTGTATTTCACAACCGAGCCCTAGCGCCAGCTCAGCACCCTACG...
Task1_train_48339	Given a variant located on Chromosome 21, assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.	Benign	TTTAGTTGTTTTTAAAACATAAAGTTTAGAATTAGCTGCACAGGTTTGACTAAAAATCCCGTTGAAATTTTAGCTGAGGCAGCATCCGATTTTTCCGGAGTAACTGACAGAGAAGAACTGCACTCTCCCGTTGGTTCTCCTGGCTGCTTGGAAGCTGGTGTTTGTGTGGGACCTCCCCTAGGTGCTGCAGATGAGAGCAGTGCTGAGTGTTCCCAGGCCGTGGGTCCCGCCCCGCCACTGCCTCGCTCCCTCCCTCCCCCTCAGAATTGAGTGGGCCGGGTGGGATTGTCGATATTGTGGTCATCTTTTCCTTGCTCGGA...	TTTAGTTGTTTTTAAAACATAAAGTTTAGAATTAGCTGCACAGGTTTGACTAAAAATCCCGTTGAAATTTTAGCTGAGGCAGCATCCGATTTTTCCGGAGTAACTGACAGAGAAGAACTGCACTCTCCCGTTGGTTCTCCTGGCTGCTTGGAAGCTGGTGTTTGTGTGGGACCTCCCCTAGGTGCTGCAGATGAGAGCAGTGCTGAGTGTTCCCAGGCCGTGGGTCCCGCCCCGCCACTGCCTCGCTCCCTCCCTCCCCCTCAGAATTGAGTGGGCCGGGTGGGATTGTCGATATTGTGGTCATCTTTTCCTTGCTCGGA...